Nephronectin Is Correlated With Poor Prognosis In Breast Cancer And Promotes Metastasis Via Its Integrin-Binding Motifs

    March 2018 in “ Neoplasia ”
    Tonje S. Steigedal, Jimita Toraskar, Richard P. Redvers, Marit Valla, Synnøve Norvoll Magnussen, Anna M. Bofin, Signe Opdahl, Steinar Lundgren, Bedrich L. Eckhardt, John M. Lamar, Judy P. Doherty, Richard O. Hynes, Robin L. Anderson, Gunbjørg Svineng
    TLDR Nephronectin is linked to worse breast cancer outcomes and helps cancer spread.
    The study analyzed nephronectin (NPNT) expression in breast cancer tissue from 842 patients, revealing that granular cytoplasmic staining of NPNT in less than 10% of tumor cells was associated with poor prognosis. The research suggested that this staining pattern might indicate NPNT-positive exosomes. NPNT was found to promote adhesion and anchorage-independent growth through its integrin-binding motifs, enhancing breast tumor cell colonization in the lungs. The findings proposed NPNT as a potential novel prognostic marker for a subgroup of breast cancer patients, highlighting its role in metastasis and potential as a therapeutic target.
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