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Stem cells are crucial for skin repair and new treatments for chronic wounds.

Understanding where cancer cells come from helps create better prevention and treatment methods.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Tofacitinib is safe and effective for severe alopecia areata, but hair loss may return 2 months after stopping treatment.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

The Rotterdam Study aims to understand various diseases in older adults.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Tiny pollution particles called PM2.5 can harm skin cells by causing stress, damage to cell parts, and cell death.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

MK-0773 safely increased muscle mass but did not improve muscle strength or function in elderly women with sarcopenia.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Finasteride effectively treats BPH, but needs more trials to understand potential.

Hair color production in mice is closely linked to the hair growth phase and may also influence hair growth itself.

Androgens can both increase and decrease hair growth in different parts of the body.

Pregnancy can cause various skin changes and diseases, with PUPPP being the most common skin condition specific to pregnancy.

Male and female skin differ in many ways, which could lead to gender-specific skin treatments.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

Sebocytes play a key role in controlling androgen levels in human skin.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Fungi-produced compounds can change plant root growth.

Targeted cancer therapies often cause serious skin problems that need careful management.

Women with PCOS are more likely to have impaired glucose tolerance and type 2 diabetes, especially if they are Asian or obese.

Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.