32 citations
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January 2000 in “Skin pharmacology and physiology” In this study, procyanidin B-2 and C-1 were found to promote hair growth by selectively inhibiting protein kinase C, supporting their potential use for hair-growing activity.
August 2026 in “Cell Biomaterials” D-chiral biomaterial scaffolds enhance tissue and hair regeneration by activating the body's immune system.
May 2026 in “International Journal of Molecular Sciences” This study suggests that hydroxytyrosol may influence inflammation and oxidative stress pathways in androgenetic alopecia, particularly through interaction with the PTGS2 gene, warranting further experimental validation.
December 2025 in “Antioxidants” This study reported that fermented yeast complex extract may promote hair regrowth by modulating antioxidative and anti-inflammatory pathways in dermal papilla cells and increasing hair follicle numbers in an animal model.
February 2024 in “Molecules/Molecules online/Molecules annual” In this study, NMN was found to reverse hair follicle atrophy, thinning, and sparsity in mice induced by DHT, and significantly decreased DHT-induced inflammation and oxidative stress in cultured human dermal papilla cells, enhancing hair growth-related markers.
52 citations
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October 2016 in “Clinics in Dermatology” This review discusses various drugs that can cause drug-induced acne, noting specific clinical and histopathologic features, but reports no new clinical findings.
20 citations
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January 2016 in “International journal of trichology” In this study, premature hair graying in Indian patients under 25 was associated with low levels of serum ferritin, Vitamin B12, and high-density lipoprotein cholesterol.
11 citations
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June 2020 in “Russian Open Medical Journal” This study found a higher frequency of below normal ferritin and serum iron levels in women with melasma compared to controls, suggesting a possible association with melasma.
December 2025 in “International Journal of Innovative Technologies in Social Science” This narrative review assesses evidence on the role of oral supplements in reducing common side effects caused by isotretinoin treatment for acne vulgaris, with the aim of providing guidance for enhancing treatment tolerability.
August 2024 in “Journal of the Association of Physicians of India” This study examined 1,992 patients at a hospital in India for signs of B12 deficiency and found common symptoms included hair loss, poor memory, and weakness. The study also reported that adding vitamin B12 powder to prepared food could improve blood levels of the vitamin.
This review discusses the role of nutrients in hair graying management and finds a possible link between low copper, iron, and vitamin B12 levels and premature hair graying.
In this study, researchers observed that individuals with acne vulgaris in the Qassim Region of Saudi Arabia had a significantly higher rate of vitamin B12 deficiency, suggesting a potential association that warrants further investigation.
December 2021 in “Dermatology research” This study found that individuals with premature graying of hair had significantly lower serum levels of vitamin B12, ferritin, and calcium compared to those without premature graying.
63 citations
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May 2017 in “American Journal of Clinical Dermatology” This review found that patients with alopecia areata may have lower levels of vitamin D, zinc, and folate, but conflicting evidence precludes definitive clinical recommendations for micronutrient supplementation.
134 citations
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December 2018 in “Dermatology and Therapy” This review discusses the potential role of vitamins and minerals in managing non-scarring alopecia but reports no clinical results; the authors advocate for further controlled trials to explore these relationships.
50 citations
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November 2010 in “Otolaryngologic Clinics of North America” This review discusses the oral manifestations associated with hematologic conditions and nutritional deficiencies, without presenting new research results; it emphasizes the impact of blood disorders and vitamin deficiencies on oral health.
43 citations
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October 1955 in “The journal of nutrition/The Journal of nutrition” This study found that male germ-free rats fed semisynthetic diets do not grow as rapidly as their conventional counterparts and require dietary biotin for normal metabolism and folic acid biosynthesis.
25 citations
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January 2017 in “International Journal of Trichology” This study found that nutritional deficiencies, particularly in amino acids and certain micronutrients, are common in individuals with hair loss across all types of alopecia.
19 citations
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March 2021 in “Obesity surgery” This study found that hair loss is common following metabolic and bariatric surgery, particularly among younger women with low serum levels of zinc, folic acid, and ferritin.
19 citations
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January 2016 in “Dermatology Research and Practice” This study observed that telogen effluvium was the most common form of acquired alopecia among females in a semiurban Indian population, with stress and chemical exposure as major exacerbating factors.
17 citations
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May 2018 in “Journal of Cosmetic Dermatology” This study reports that nonscarring diffuse hair loss in women is most common in the 21-40 age group, with low serum ferritin, vitamin B12, and vitamin D3 levels contributing to its pathogenesis.
16 citations
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January 2018 in “International journal of trichology” This study observed that individuals with premature hair graying had lower levels of certain serum nutrients and lifestyle factors like stress and smoking may contribute; hair oiling appeared protective.
13 citations
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July 2018 in “Obesity surgery” This study found that 56% of patients experienced hair loss six months after undergoing laparoscopic sleeve gastrectomy, with lower preoperative and postoperative zinc and vitamin B12 levels associated with this outcome.
10 citations
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August 2021 in “Journal of Cosmetic Dermatology” This study retrospectively analyzed 3028 patients with telogen effluvium, finding that 6.2% had iron deficiency anemia and vitamin D deficiency was common, especially in women who were more often prescribed vitamin D therapy.
8 citations
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September 2021 in “Journal of Cosmetic Dermatology” This review discusses the varied levels of evidence linking nutritional supplements and antioxidants to dermatological disorders, but it reports no new clinical results and highlights the need for rigorous trials.
7 citations
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October 2020 in “Dermatology practical & conceptual” This review discusses the potential risks associated with skin, hair, and nail supplements, highlighting concerns about safety, efficacy, and lack of regulation but reports no new clinical results.
5 citations
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December 2020 in “BMC Dermatology” This study observed that successful weight loss following bariatric surgery may improve some skin conditions and metabolic profiles, but also may lead to a decrease in vitamin B12 levels, suggesting a need for nutritional supplements.
5 citations
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January 2006 in “Journal of obstetrics and gynaecology” Metformin can cause hair loss in some women with PCOS.
4 citations
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May 2019 in “Zeitschrift für Naturforschung C” This study found that Ishige sinicola extract stimulated osteoblast differentiation and bone formation in MC3T3-E1 cells, suggesting potential use for osteoporosis prevention and treatment.
4 citations
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March 2006 in “Journal of renal nutrition” This study found that hemodialysis patients taking water-soluble vitamins had a 16% lower mortality risk compared to those not taking any, but the specific supplementation needed remains unclear.