10 citations
,
November 1946 in “Journal of the American Medical Association” This study reported that severe hair disturbances in infants and young children are associated with acute vitamin deficiencies in tropical America, unlike the milder cases observed in the United States.
October 1940 in “Clinical and Experimental Optometry” In this study, adult albino rats on a vitamin A deficient diet developed ocular symptoms like xerophthalmia and photophobia within four weeks, without showing loss of dark adaptation.
44 citations
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September 1948 in “Radiology” This article reports that hypervitaminosis A in both experimental rats and children leads to severe symptoms such as weight loss, bone issues, and skin problems, which resolve upon stopping vitamin A intake.
52 citations
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May 1982 in “The American journal of the medical sciences” This study found that the most likely cause of hypercalcemia in a patient with symptoms of hypervitaminosis A and a history of chronic vitamin A ingestion was vitamin A toxicity.
May 2024 in “Endocrine practice” In this case report, researchers identified Vitamin A toxicity as the cause of refractory hypercalcemia in a nonverbal patient, emphasizing the difficulty of diagnosing this rare condition due to its nonspecific symptoms.
This case study reports that prolonged high-dose vitamin A intake led to multiple adverse health effects in a young man, which mostly resolved after stopping the supplement, although liver changes persisted.
24 citations
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July 1979 in “Archives of Dermatology” This article discusses the potential for hypervitaminosis A in patients with chronic renal disease undergoing dialysis, highlighting the risks associated with low-dose vitamin A supplementation, and reports no new clinical results.
7 citations
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July 1979 in “Archives of Dermatology” This article discusses the case of a patient on long-term renal dialysis with high serum vitamin A levels likely due to inadequate removal during dialysis, highlighting the need to reassess vitamin A supplementation in such patients.
28 citations
,
March 1986 in “The American journal of medicine” This study presented two cases of chronic hypervitaminosis A in adults, highlighting the first reported instance of hepatic cirrhosis due to long-term beef liver consumption.
September 2024 in “Meditsinskiy sovet = Medical Council” This article reports a rare case of toxic keratitis in a patient due to excessive intake of vitamin A, highlighting hypervitaminosis A risks such as severe eye conditions and systemic health issues, especially with cumulative doses exceeding therapeutic levels.
1 citations
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February 2022 in “Terapevtičeskij arhiv” This case report describes severe liver injury in a young patient after prolonged overuse of vitamin A, which resolved after cessation.
32 citations
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January 2006 in “Liver transplantation” This case report describes a 60-year-old male with vitamin A toxicity leading to severe liver disease and symptoms that resolved following liver transplantation, suggesting transplantation as a treatment option for noncirrhotic portal hypertension when symptoms do not improve after stopping vitamin A.
2 citations
,
February 1945 in “Archives of Dermatology and Syphilology” This case report describes a woman with an unusual presentation of tinea capitis, noting diagnostic challenges as initial examinations found no mycelium or spores.
88 citations
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October 1983 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” In this study, distinct clinical responses and long-term resistances were observed in two pediatric patients with vitamin D-dependency type II, associated with abnormalities in their skin fibroblast interactions with 1,25-(OH)2D3.
August 2025 in “Quality in Sport” In this review, the authors highlighted the importance of vitamin A for vision, immune function, growth, and skin, noting that deficiency can lead to serious health issues like night blindness and increased infection risk, while excessive intake poses toxicity risks, particularly from supplements.
6 citations
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October 1980 in “Archives of Dermatology” This review discusses various metabolic and vitamin disorders affecting hair structure, including Menkes' syndrome, arginosuccinicaciduria, and recent findings on vitamin-related alopecia, but reports no new clinical results.
7 citations
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May 2012 in “Journal of veterinary diagnostic investigation” This study reports that vitamin A deficiency can cause dermatologic issues like alopecia and orthokeratosis in Angus calves, and affected calves improved with vitamin A supplementation.
170 citations
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May 1979 in “The journal of pediatrics/The Journal of pediatrics” This report describes two sisters with rickets and alopecia unresponsive to high doses of vitamin D2, where oral phosphorus supplements led to significant clinical improvement.
8 citations
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August 1970 in “JAMA” This letter describes cases in which papilledema and other symptoms in young girls were attributed to hypervitaminosis A.
14 citations
,
October 2023 This article summarizes the essential roles and effects of deficiencies of both fat-soluble and water-soluble vitamins, noting issues ranging from blindness due to vitamin A deficiency to scurvy caused by a lack of vitamin C.
82 citations
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October 1980 in “The Journal of Clinical Endocrinology & Metabolism” This case study describes a child with an unusual form of vitamin D-dependent rickets, characterized by alopecia and a deficient response to active vitamin D.
82 citations
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April 1981 in “Clinical endocrinology” This study describes a case of vitamin D resistant rickets in a young girl due to end organ unresponsiveness, highlighting a possible new subtype of the disorder with distinct clinical features.
June 2021 in “Asian Journal of Medical Sciences” This case study highlights that vitamin B12 deficiency can cause reversible hyperpigmentation, illustrated by a vegetarian female patient whose skin lesions improved after treatment.
3 citations
,
August 2005 in “Journal of Pediatric Gastroenterology and Nutrition” This case report identifies chronic vitamin A intoxication in a toddler who received excessive vitamin A supplements, resulting in various symptoms and confirmed by liver biopsy findings.
2 citations
,
June 1972 in “PubMed”
5 citations
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January 1970 in “Journal of Nepal Paediatric Society” This article reviews Vitamin D-dependent rickets Type II with a focus on alopecia as a potential diagnostic clue for this rare disorder, reporting no new clinical findings.
January 2024 in “Clinical, cosmetic and investigational dermatology” In this case report, a four-year-old girl was diagnosed with vitamin D-dependent rickets type II, manifesting as diffuse alopecia, frontal bossing, hypoplastic teeth, and skin-colored papules, due to a genetic mutation causing resistance to 1.25-dihydroxy vitamin D.
4 citations
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March 2020 in “JAAD Case Reports” This case report describes a 47-year-old male with rare total melanonychia linked to vitamin B12 deficiency, whose nail discoloration and constitutional symptoms improved following vitamin B12 supplementation.
9 citations
,
December 1987 in “Archives of Dermatology” This study highlights two newly discovered metabolic disorders of biotin, showing distinct skin and hair symptoms and severe complications like acidosis and ketosis.
1 citations
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January 2016 in “Journal of Nepal Paediatric Society” This case report discusses a 27-month-old girl with vitamin D-dependent rickets type II, who showed minor improvement in skeletal features and alopecia after high-dose oral calcium and vitamin D3 treatment.