A Systemic-Like Disease: Chronic Vitamin A Poisoning

January 1986 in “ PubMed ”

Anne–Catherine Baglin, C Hagege, Brigitte Franc, M Richaud, J Prinseau

vitamin A poisoning hair loss skin dryness peeling liver enlargement ascites pleural effusion hypercalcemia acute renal failure liver fibrosis

TLDR Excessive vitamin A intake caused severe health issues that mostly resolved after stopping the intake.

A 22-year-old man ingested over 300 million I.U. of vitamin A over 2 years, leading to symptoms like diffuse arthralgia, weight loss, low-grade fever, skin dryness and peeling, hair loss, liver enlargement with ascites, and pleural effusion. Despite normal plasma levels of vitamin A and retinol-binding protein, he had raised E.S.R., hypercalcemia, and acute renal failure. Symptoms resolved after stopping vitamin A, except for liver enlargement. Biopsies showed high liver vitamin A levels, cortical bone thickening, and liver fibrosis development.

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research A Systemic-Like Disease: Chronic Vitamin A Poisoning

January 1986 in “PubMed”

Excessive vitamin A intake caused severe health issues that mostly resolved after stopping the intake.