August 2024 in “Qucosa (Saxon State and University Library Dresden)” In this study on mice, researchers observed that dermal white adipose tissue (dWAT) plays a key role in regulating skin inflammation and tissue repair; however, reduced expression of certain cytokines in obese mice may hinder these processes, indicating potential metabolic disruptions in dWAT during inflammation.
This case report highlights the successful treatment of a 37-year-old male with steroid-resistant beard alopecia areata using baricitinib, a JAK-1/2 inhibitor, over 9 months, resulting in reduced hair loss and improved hair density.
53 citations
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July 2018 in “Drug design, development and therapy” This review summarizes existing evidence on the efficacy and safety of JAK inhibitors for treating alopecia areata and emphasizes the need for improved topical formulations.
7 citations
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December 2016 in “Journal of the American Academy of Dermatology” In this study, researchers found that patients with alopecia areata had a significant increase in NKG2D+CD4+ T cell levels in their blood compared to healthy controls.
2 citations
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October 2022 in “Journal of Biomedical Science” This review discusses the potential of secretome derived from stem cells for treating alopecia areata and reports no new clinical results; the authors suggest the need for further human trials.
1 citations
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November 2023 in “Journal of neurology” This study reports a case of a patient with neuromyelitis optica spectrum disorders treated with eculizumab who developed fatal sepsis after insulin resistance emerged.
This study observed two distinct groups of alopecia areata lesions based on PD-1 expression in T cells from biopsied skin samples, suggesting potential differences in subtypes or stages of the disease that warrant further investigation.
This study identified significant differences in KIR gene profiles between SLE patients and controls, suggesting that specific KIR genes could serve as biomarkers for disease severity in Indian SLE patients.
December 2023 in “Journal of Ayub Medical College Abbottabad” In this study, Ritlecitinib was reported as a newly approved treatment for alopecia areata that can be used in patients aged 12 and older; after 24 weeks, it resulted in 80% or more scalp hair coverage in treated patients compared to a placebo.
45 citations
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April 2019 in “International Immunology” This review discusses the mechanisms behind alopecia areata and primary cicatricial alopecia and reports no new clinical results, aiming to guide the development of targeted treatments.
11 citations
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March 2013 in “Journal of Ophthalmic Inflammation and Infection” This report describes two cases of VKH disease and SO where severe alopecia, likely due to incomplete treatment, improved following systemic steroid therapy.
2 citations
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May 2022 in “Cosmetics” This review explores the potential roles of the gut and skin microbiome in alopecia areata, suggesting topical and systemic strategies for managing the condition, but it reports no new clinical results.
In this study on C3H/HeJ-engrafted mice, a single injection of BMD-1141 significantly increased anagen hair follicle counts and enhanced hair regrowth compared to daily high-dose ruxolitinib, suggesting it stimulates hair growth by influencing the hair cycle rather than altering immune response.
11 citations
,
September 2022 in “The Journal of Rheumatology” This article discusses the classification and significance of cutaneous manifestations in systemic lupus erythematosus, emphasizing the importance of recognizing these skin features for disease management, but reports no new clinical results.
6 citations
,
January 2005 in “Biology of Blood and Marrow Transplantation” This article reviews various models of graft-versus-host disease, highlighting the complexity of its mechanisms and the challenges in interpreting histopathologic data; it reports no new results.
2 citations
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May 2023 in “Journal of Indian Society of Periodontology” This review suggests a potential link between alopecia areata and periodontitis, emphasizing the importance of interdisciplinary approaches, including dental assessments and treatments, to potentially improve outcomes for patients with unexplained alopecia.
1 citations
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January 2018 This review discusses factors affecting thyroid function and Hashimoto's thyroiditis, mentioning treatment options, but reports no new clinical findings; the need for nutrient consideration is emphasized.
In this case study, a nine-year-old boy with alopecia universalis following severe chickenpox showed complete hair regrowth after treatment with tofacitinib, suggesting the drug's potential in managing varicella-zoster virus-induced alopecia by modulating immune responses.
April 2017 in “Journal of Investigative Dermatology” This research explores the potential role of the Stx17 protein in hair pigmentation processes and Alopecia Areata, suggesting possible links to the disease's progression.
32 citations
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August 2003 in “Journal of the European Academy of Dermatology and Venereology” This article reviews the clinical aspects and potential mechanisms of chronic graft vs host disease skin manifestations, describing a novel form of premature skin aging, but presents no new research findings.
9 citations
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January 2015 in “Annals of dermatology/Annals of Dermatology” This retrospective study concluded that alopecia areata in elderly patients showed mild severity and a favorable treatment response, with no link found between hair graying and the extent of hair loss.
8 citations
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January 2018 in “Middle East Journal of Digestive Diseases” This case report describes a middle-aged man with alopecia universalis and ulcerative colitis, where hair regrowth occurred following treatment with azathioprine and mesalamine.
3 citations
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June 2025 in “Biomedicines” This review discusses the potential link between gut microbiota alterations and the onset and progression of alopecia areata, identifying it as a possible pathogenetic factor and therapeutic target, but reports no new clinical results.
2 citations
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May 2023 in “Photobiomodulation, photomedicine, and laser surgery” This editorial reviews how photobiomodulation therapy might effectively treat both hyperpigmentation and depigmentation skin disorders, but reports no new clinical results.
January 2024 in “Case Reports in Endocrinology” In this case report, significant improvements in a 58-year-old male with severe refractory myasthenia gravis and concurrent alopecia areata were observed following a cortisone taper, suggesting a potential therapeutic role, especially after thymectomy.
January 2024 in “Pharmaceutical journal/The pharmaceutical journal” In this report, NICE has approved ritlecitinib, an oral kinase inhibitor, as the first recommended treatment for severe alopecia areata in individuals aged 12 and older.
26 citations
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June 2024 in “Frontiers in Immunology” The authors discussed that SOCS1 and SOCS3's inhibition of JAKs plays a significant role in the development of JAK inhibitor drugs for skin inflammatory diseases and malignancies.
26 citations
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April 2023 in “Medicina” This systematic review suggests that platelet-rich plasma may significantly improve symptoms in oral lichen planus with effects comparable to corticosteroids, although more research is needed to confirm these findings.
139 citations
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October 2005 in “Journal of Investigative Dermatology” This study describes previously unknown immune characteristics of the normal human nail, highlighting its similarities to the hair follicle immune system and suggesting an immune privilege in the proximal nail matrix that both provides autoimmunity protection and presents infection susceptibility.
2 citations
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July 2022 in “Cell Regeneration” This review discusses the complex interplay of factors controlling hair regeneration and highlights the potential for targeted clinical applications in various hair disorders, while reporting no new clinical results.