This study found that the crude extract of Hibiscus rosa-sinensis leaves, whether irradiated or not, showed significant antioxidant activity without causing toxicity in rats, suggesting gamma radiation may enhance its therapeutic properties.
October 2015 in “Digital Library of Theses and Dissertations (Universidade de São Paulo)” This study observed smaller reductions in PSA levels in men under 40 taking finasteride 1mg/day compared to older age groups, without changes in testosterone levels.
Hair movement can indicate hair quality and health.
January 2008 in “LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)” This study found that the gene for the enzyme aromatase is expressed in scalp hair follicles of women and is negatively correlated with LH levels, potentially reflecting the hormonal environment of hair follicles in PCOS.
This compilation lists potential side effects, drug interactions, and trade names of various dermatological and antiretroviral medications, but it reports no original research findings.
January 2023 in “Revista Ibero-Americana de Humanidades, Ciências e Educação” This source explores treatments for male-pattern baldness, highlighting finasteride, which reduces DHT levels to support hair growth, and minoxidil, used for vasodilation and hair health, though the exact mechanisms remain partly unclear.
November 2021 in “Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo” This review of current research suggests that combining microneedling with minoxidil, and possibly platelet-rich plasma or mesotherapy, may achieve better hair growth results for androgenetic alopecia than conventional methods.
3 citations
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August 2020 in “Cutaneous and Ocular Toxicology” This study demonstrated that adenosine triphosphate may prevent vandetanib-induced skin toxicity in rats, suggesting potential for further research in other animal models and humans.
503 citations
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May 2009 in “Cell stem cell” This study suggests that Lrig1-positive cells form a previously unknown reservoir of interfollicular epidermal stem cells in adult mouse skin, influencing epidermal proliferation and hair follicle development.
489 citations
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November 2021 in “Signal Transduction and Targeted Therapy” This review discusses the composition, activation, and regulation of the JAK/STAT pathway and highlights its role and inhibitors in various diseases, but reports no new experimental results.
247 citations
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June 2021 in “Frontiers in Cell and Developmental Biology” This review discusses the role of lncRNA Xist in cell growth regulation and disease development, particularly cancer, and reports no new experimental results.
223 citations
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June 2018 in “Human Reproduction Update” This study concluded that including ovarian morphology in the diagnosis significantly increases the estimated prevalence of PCOS, revealing substantial variability due to clinical criteria and diagnostic cut-offs.
146 citations
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January 2004 in “Hormones” This review explores the complex endocrine functions of human skin and its role as a peripheral endocrine organ, but reports no new clinical results.
143 citations
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May 2022 in “Pharmaceuticals” This review discusses alginate-based delivery systems for probiotics, highlighting recent advances, challenges, and future directions, but reports no new clinical findings.
114 citations
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August 2002 in “Journal of Investigative Dermatology” Alopecia areata is caused by an immune response, and targeting immune cells might help treat it.
91 citations
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November 2008 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that DGAT1 functions as a key enzyme in murine skin to regulate retinoic acid levels and prevent retinoid toxicity, impacting hair cycle and sensitivity to retinol.
82 citations
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July 2012 in “Brain pathology” This study found that LGR5 may play a significant role in maintaining brain cancer stem-like cells and is associated with glioma progression and poor outcomes.
72 citations
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November 2020 in “Frontiers in Pharmacology” This review highlights potential benefits of jujube fruits on blood health, suggesting they might aid anemia prevention or treatment by supporting erythropoiesis and immune regulation, based on evidence from cell and animal studies.
71 citations
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July 2018 in “Revista do Colégio Brasileiro de Cirurgiões” This study found that bariatric surgery effectively treated morbid obesity and improved quality of life and the resolution of comorbidities for most patients.
69 citations
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February 2019 in “Industrial Crops and Products” Zizyphus lotus leaves and fruits have strong antidiabetic effects and potential skin benefits.
59 citations
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September 2021 in “Cosmetics” This review discusses lipid nanoparticle-based cosmetics, emphasizing their potential in protecting skin from radiation and treating conditions like atopic dermatitis and psoriasis with synthetic and natural antioxidants. It highlights recent research on these formulations' effectiveness in alleviating skin disorders and enhancing skin health.
57 citations
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May 2021 in “Molecules” This review explores the chemical composition and biological activities of essential oils from selected aromatic roots, highlighting their potential for various industries, though more research is needed to standardize their bioactive components.
56 citations
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January 2023 in “Genes & Diseases” This study discusses a hypothesis for repurposing non-cancer drugs and combining micronutrients to target cancer and cancer stem cells with fewer side effects, suggesting a potential new approach for more effective cancer therapy.
52 citations
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February 2003 in “Archives of dermatology” In this open-label trial, 9-cis-retinoic acid showed moderate activity against Kaposi sarcoma in AIDS patients, but its use is limited by substantial side effects at higher doses.
52 citations
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July 1998 in “Urology” This study found that liarozole is more effective than cyproterone acetate for improving PSA response and survival in metastatic prostate cancer after first-line endocrine therapy, while maintaining quality of life.
49 citations
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November 2022 in “Life” This review discusses global variations in polycystic ovary syndrome prevalence and highlights the need for more comprehensive studies to understand its association with race, ethnicity, and diagnosis criteria; it reports no new results.
48 citations
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July 2022 in “International Journal of Nanomedicine” This review discusses nanotechnology-based therapies for chronic wound healing and highlights their potential, but it reports no new clinical results.
47 citations
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January 2003 in “Pharmaceutical Research” 46 citations
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October 2025 in “Journal of Nanobiotechnology” This review examines the potential of plant-derived exosome-like nanovesicles in dermatology, highlighting their bioactive properties and discussing challenges to their clinical application, but does not provide new clinical results.
44 citations
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May 2023 in “MedComm” This review highlights the potential of PROTAC technology in drug discovery for previously undruggable targets, particularly in cancer therapy, while emphasizing the urgent need to discover more E3 ligase recruiters to optimize targeted protein degradation.