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570-600 / 1000+ resultsresearch Adverse Effects and Safety of 5-alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review.
This review discusses the adverse events associated with 5-alpha reductase inhibitors, finding them generally well-tolerated but noting potential risks like sexual side effects and psychological effects in men, and sparse data on use in women.
research The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease
AKR1B10 enzyme may cause keloid scars and could be a treatment target.
research Neuropeptídeos na pele
This review discusses the roles of several neuropeptides in skin-immune interactions and inflammatory responses, reporting no new results and emphasizing the need for further study in conditions such as psoriasis and dermatitis.
research The impact of VDR expression and regulation in vivo
This study found that humanized mouse models expressing mutated or reduced levels of the vitamin D receptor were able to maintain normal mineral homeostasis and prevent typical symptoms of vitamin D resistance.
research Liposomes and Other Nanocarriers for the Treatment of Acne Vulgaris: Improved Therapeutic Efficacy and Skin Tolerability
This article outlines how nanotechnology strategies, including phospholipid-based nanocarriers like liposomes, could enhance the effectiveness and skin tolerability of acne treatments, aiming to reduce side effects and improve patient compliance in managing acne vulgaris.
research Expression Profiles of Reproduction- and Thyroid Hormone-Related Transcripts in the Brains of Chemically-Induced Intersex Frogs
This study observed that chemically-induced intersex frogs displayed altered brain mRNA profiles, with finasteride increasing certain hormone-related gene expressions and fadrozole reducing aromatase activity without affecting gene transcript levels.
research lncRNA H19 acts as a ceRNA to regulate the expression of CTGF by targeting miR-19b in polycystic ovary syndrome
This study found that lncRNA H19 may regulate CTGF expression in KGN cells by acting as a "sponge" for miR-19b, potentially influencing polycystic ovary syndrome development.
research Delivery systems in nanocosmeceuticals
This review explores how nanoparticles enhance cosmeceutical formulations, analyzing their roles in transporting active ingredients, and highlights the progress and challenges in using nanotechnology for beauty and health products.
research Ethnobotanical Survey of Natural Galactagogues Prescribed in Traditional Chinese Medicine Pharmacies in Taiwan
This study identified key natural medicinal materials used in traditional Chinese medicine across Taiwan for inducing lactation, highlighting Angelica sinensis as a primary core component in galactogenous prescriptions.
research Epidermal stem cells: skin surveillance and clinical perspective
This review explores recent advancements in understanding how various physiological and psychological factors, such as stress and aging, influence epidermal stem cell populations, highlighting their importance in immune-related skin disorders and potential for clinical applications.
research Teratogenic effect of isotretinoin in both fertile females and males (Review)
This review examines recent literature on isotretinoin's teratogenic effects in both fertile females and males, analyzing its role in causing congenital malformations but provides no new clinical results.
research Dietary Supplements in Chemotherapy-Induced Peripheral Neuropathy: A New Hope?
This review discusses potential agents, including acetyl-L-carnitine and vitamins, for repurposing in managing chemotherapy-induced peripheral neuropathy and reports no clinical results; the authors emphasize the need for further research.
research Androgenetic alopecia.
This article reviews current diagnostic and treatment approaches for androgenetic alopecia but reports no new results, focusing on its progression and medical management options.
research Vitamin A in Skin and Hair: An Update
This review discusses new research on the role of retinoids in skin and hair health and reports no clinical results.
research The Necessity to Investigate In Vivo Fate of Nanoparticle-Loaded Dissolving Microneedles
This review highlights that while nanoparticle-loaded dissolving microneedles have considerable promise for enhancing transdermal drug delivery, progress is delayed by insufficient understanding of their in vivo behavior, which the authors emphasize as crucial for advancing clinical applications.
research Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis
iNKT cells help develop and maintain healthy skin in young mice.
research Prevention of Male Late-Onset Hypogonadism by Natural Polyphenolic Antioxidants
In this review, researchers highlighted that natural polyphenolics like flavonoids and resveratrol may help enhance testosterone production in aging males by boosting the expression of the Star gene in Leydig cells, potentially preventing age-related degenerative conditions linked to testosterone insufficiency.
research Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?
This review discusses the potential role of nutraceuticals in preventing and treating COVID-19 and post-COVID syndrome, but reports no new clinical findings; the authors highlight the need for further research.
research Proteolysis‐Targeting Chimera (PROTAC): Current Applications and Future Directions
This review discusses the development and clinical progression of PROTAC technology for targeted protein degradation, highlighting its potential to address previously "undruggable" targets but reports no new clinical results.
research The therapeutic, diagnostic, and prognostic values of extracellular vesicles (exosomes) in dermatology: A systematic review
This review discusses the role of extracellular vesicles in dermatology for therapeutic, diagnostic, and prognostic purposes, highlighting the lack of validated findings and the necessity for more rigorous clinical trials.
research Solubility of Foreign Molecules in Stratum Corneum Brick and Mortar Structure
This study presents a method for directly measuring the solubility of solid chemicals in the skin's stratum corneum under various humidity conditions, emphasizing its importance for dermal drug delivery and chemical safety assessments.
research Shengfu Oil Enhances the Healing of Full-Thickness Scalded Skin Accompanying the Differential Regulation of β-Catenin, Dlk1, and COX-2
This study found that Shengfu oil may enhance wound healing in scalded rabbit skin by regulating proteins β-catenin, Dlk1, and COX-2, due to its anti-inflammatory, analgesic, and antimicrobial properties.
research Progress in Lipid and Inorganic Nanocarriers for Enhanced Skin Drug Delivery
This review examines advancements in lipid and inorganic nanocarriers, such as liposomes and inorganic nanoparticles, for transdermal drug delivery, noting enhanced absorption and stability but acknowledging that few have reached clinical use.
research Implication of microRNA regulation in para-phenylenediamine-induced cell death and senescence in normal human hair dermal papilla cells
This study found that para-phenylenediamine induces cytotoxic effects in normal human hair dermal papilla cells by altering microRNA expression and causing cell death, cell cycle arrest, and oxidative stress.
research Stimuli-responsive nanoformulations for CRISPR-Cas9 genome editing
This review discusses recent advances in stimuli-responsive nanoformulations for CRISPR-Cas9 delivery, highlighting their design rationales and potential biomedical applications, but reports no new experimental results.
research β-sitosterol in Yijing Hugui decoction prevents cyclophosphamide-induced premature ovarian insufficiency via the AKT1/Nrf2 pathway
research Application of Advanced Platelet-Rich Fibrin in Oral and Maxillo-Facial Surgery: A Systematic Review
This review discusses the role of advanced platelet-rich fibrin (A-PRF) in oral and maxillofacial surgery, highlighting its potential benefits for healing, pain relief, and graft integration, with a need for more clinical trials to confirm long-term effects.
research RAPID ALKALINIZATION FACTOR 22 is a key modulator of the root hair growth responses to fungal ethylene emissions in Arabidopsis
This study in Arabidopsis thaliana found that exposure to volatile compounds from Penicillium aurantiogriseum promotes root hair growth through signaling involving RALF22, ethylene, auxin, and photosynthesis, and that RALF22 plays a crucial role in the plants' response to these compounds.
research Comparative study on eucalyptol and camphor rich essential oils from rhizomes of Hedychium spicatum Sm. and their pharmacological, antioxidant and antifungal activities
This study found that essential oils from Hedychium spicatum showed anti-inflammatory, antinociceptive, antipyretic, and antioxidant activities, with site-specific variations in their effectiveness.