July 2022 in “Journal of Investigative Dermatology” This study found that Substance P increased mitochondrial activity and biogenesis markers in cultured human scalp hair follicles, suggesting a novel link between stress-related neuropeptide signaling and hair follicle mitochondrial responses.
1 citations
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January 2003 in “Benjamins eBooks” This study found no significant difference in hair cortisol concentrations between sows confined in farrowing crates and those in loose-housing systems, suggesting confinement may not affect chronic stress levels.
This study found that in sleep-deprived rats, increased 5α-reductase expression and activity in the prefrontal cortex contributed to psychosis- and mania-like symptoms, which finasteride ameliorated in a dose-dependent manner.
2 citations
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August 2020 in “Our Dermatology Online” This study found that stress appears to significantly contribute to the onset and worsening of alopecia areata.
May 2024 in “Reactions weekly”
This study of androgenic alopecia patients reports that stress was associated with AGA in both men and women, with notable findings differing by gender, age, and AGA type.
September 2025 in “Cosmoderma” This study highlights how the COVID-19 pandemic has exacerbated stress-related dermatological issues like acne and hair loss by affecting skin and hair cycles through stress hormones, emphasizing the need for comprehensive psychoneuroendocrine-informed approaches to diagnosis and treatment.
July 2013 in “Journal of clinical & experimental dermatology research” This study found that prototype right heart circulatory assist devices significantly improved hemodynamics and reduced pulmonary vascular resistances in piglet models of acute hemodynamic shock.
3 citations
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July 2023 in “International journal of molecular sciences” This review discusses the association between emotional stress-related neuropeptides and the pathogenesis of alopecia areata, reporting no new experimental findings.
5 citations
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January 1984 in “Journal of psychosomatic obstetrics and gynecology/Journal of psychosomatic obstetrics and gynaecology” This study found that treatment with cyproterone acetate and ethinylestradiol in hirsute women reduced testosterone and androstenedione levels, decreased hair growth, and increased cortisol levels without changing catecholamine excretion.
33 citations
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November 1994 in “Archives of Biochemistry and Biophysics” 16 citations
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November 2018 in “The journal of pain/Journal of pain” This study found that in a rat model, 14,15-EET may alleviate central poststroke pain by enhancing thalamic inhibition through neurosteroid signaling, potentially outperforming gabapentin in early-stage treatment.
18 citations
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June 2010 in “Cell Stress and Chaperones” This study reported that heat treatment significantly increased the incidence of alopecia areata in C3H/HeJ mice, suggesting a role for induced HSPA1A/B expression in disease development.
16 citations
,
May 1998 in “International Journal of Dermatology” This study found that elevated serum cortisol levels and other immunological changes are significantly involved in the active phases of psoriasis eruptions.
1 citations
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March 2020 in “Journal of Pharmacological Sciences” This study demonstrated that benzothiazepines, such as diltiazem and JTV-519, exert anxiolytic-like effects through allopregnanolone biosynthesis in mice, similar to carbamazepine.
January 1999 in “대한피부과학회지” This study aimed to explore the relationship between stress and dermatologic disorders and found that the connection remains unclear, but it also examined the potential influence of coping strategies.
47 citations
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January 2024 in “iScience” The researchers reported that stress-induced keratins in human skin are expressed at lower levels than those in healthy skin and are co-regulated with genes involved in differentiation, inflammation, and immunity, rather than replacing keratins of normal differentiation or indicating cell proliferation.
January 2025 in “International Journal For Multidisciplinary Research” This article reviews stress and anxiety, noting that stress can be a normal response to life pressures but can also lead to health issues; it emphasizes that, in addition to modern management, mindfulness meditation may reduce stress and improve well-being.
This study found that women undergoing mid-trimester termination of pregnancy exhibited increased cumulative cortisol and testosterone levels in hair samples, higher anxiety, but better stress coping strategies two months post-abortion, suggesting hair testosterone may be linked to emotional vulnerability such as neuroticism during this period.
December 2025 in “Neurobiology of Stress” This study found that individuals with a recent history of suicide attempts exhibited altered DHEA hair levels, suggesting possible dysregulation of the HPA axis as a biopsychosocial feature, and recommends further investigation into hair hormones as potential markers of suicidal crisis and vulnerability.
July 2013 in “Brain and nerve : 神経研究の進歩” This study found that saponin derivatives from P chinensis may effectively block CRH receptor function and could be used to treat stress-induced hair loss.
108 citations
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July 2004 in “American Journal of Pathology” This study suggests that nerve growth factor plays a crucial role in the stress-induced termination of hair growth in mice, and its antagonism might offer a therapeutic approach to mitigate stress-related hair loss.
November 2024 in “Journal of Investigative Dermatology” This study found that recombinant human ADM2 treatment inhibited cell proliferation and induced apoptosis in human hair follicles, contrasting with the previously documented pro-proliferative and anti-apoptotic functions of ADM2.
69 citations
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August 2016 in “PubMed” This article discusses the relationship between cortisol, stress, and hair follicle function and highlights oral supplementation with a specific proteoglycan as a promising treatment for stress-related hair growth disorders, but it does not present new clinical results.
October 2025 in “International Journal of Homoeopathic Sciences” This case report details the significant hair regrowth experienced by a 49-year-old woman with stress-related alopecia totalis after individualized homeopathic treatment, underscoring its potential effectiveness in managing both emotional trauma and hair loss.
35 citations
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March 2013 in “American Journal of Medical Genetics Part B Neuropsychiatric Genetics” This study found that a genetic variation in SRD5A2 influences the severity of PTSD symptoms in a sex-specific manner among traumatized African-American males.
1 citations
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October 2023 in “Journal of the Endocrine Society” In this study, researchers found that transgender men exhibited impaired autonomic modulation during sympathetic stimulation compared to cisgender women, potentially due to testosterone treatment affecting cardiac autonomic modulation.
2 citations
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March 2025 in “Quantitative Imaging in Medicine and Surgery” In this study, patients with alopecia areata showed altered hypothalamic activity and connectivity, which may be linked to the neurophysiological basis of psychological stress experienced by these patients, as assessed by functional MRI and correlated with neuropsychological evaluations.
26 citations
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January 1994 in “Hormone and Metabolic Research” This study found that one year of antiandrogen treatment with spironolactone significantly decreased bone mineral density in young women with androgen excess.