September 2025 in “Blood Advances” This study found that targeting androgen receptors with prostate cancer drugs ARN509 and finasteride induced remission and increased survival in a leukemia mouse model, suggesting a potential new treatment approach for acute myeloid leukemia.
76 citations
,
April 2005 in “Cancer Epidemiology, Biomarkers & Prevention” This study found that the AR-E211 A allele is associated with a lower risk of both metastatic prostate cancer and androgenetic alopecia in an Australian population.
December 2025 in “Jurnal Ilmiah Kesehatan (JIKA)” This study found that a 15% concentration of Wilalondahi bark extract gel significantly improved wound healing and reduced inflammation in mice, with wounds completely healed by day 9, demonstrating comparable effectiveness to the positive control.
February 2025 in “Journal of Pharmaceutical and Health Research” This study examined the cytotoxic effects of arumanis mango rind extract and its fractions on T47D breast cancer cells, with results showing that ethanol extract and ethyl acetate fraction exhibited significant potential in reducing cell viability, similar to the effects of doxorubicin.
November 2024 in “Rheumatology Advances in Practice” This case report highlights a rare instance of visceral leishmaniasis presenting as seropositive rheumatoid arthritis in a patient with HIV, emphasizing the importance of considering chronic infections as a differential diagnosis in inflammatory arthritis, especially in diverse populations with a history of travel.
January 2004 in “Journal of Guangzhou University of Traditional Chinese Medicine” This study found that the expression of androgen receptors is higher in the scalp area affected by androgenetic alopecia, and its expression varies based on different traditional Chinese medicine syndromes.
4 citations
,
March 2019 in “Journal of Pure and Applied Microbiology” This study investigated the anti-inflammatory effects of a 940nm diode laser in Wistar rats with carrageenan-induced arthritis and found that a 74J/cm² energy density significantly reduced edema and restored function, whereas 171J/cm² neared thermal exposure limits for the skin.
In this study, the researchers reported that the optimized compound 39 demonstrated potent AR antagonism and favorable pharmacokinetics in a hair-growth mouse model, achieving similar efficacy to pyrilutamide with faster onset and preserved safety, offering promise for next-generation topical AR antagonist development.
August 2026 in “Ebers Papyrus” This study concluded that allele-specific PCR (AS-PCR) is more reliable than tetra-primer ARMS-PCR for genotyping the SNP rs1998076 due to better stability and interpretability.
4 citations
,
October 2023 in “Journal of Medicine and Life” In this study, UDCA treatment reduced inflammation, oxidative stress, and cartilage damage in rats with experimentally induced rheumatoid arthritis, suggesting potential anti-rheumatoid arthritis properties.
20 citations
,
August 2005 in “Journal of Cutaneous Pathology” This study found that in male androgenic alopecia, the androgen receptor coactivator ARA70/ELE1 exhibits differential expression patterns, suggesting its involvement in the condition.
January 2017 in “Journal of clinical & experimental dermatology research” This report describes a case of HAIR-AN syndrome in a young woman, characterized by acanthosis nigricans, insulin resistance, and polycystic ovaries, highlighting its rarity and multisystem nature.
This study found that ARHGEF3 is crucial for hair follicle development in mice, as its absence leads to defects in placode compaction and impaired follicle downgrowth, highlighting its role in regulating cell shape rearrangements during embryogenesis.
This study found that supraphysiological and physiological androgen levels inhibited U937 macrophages' phagocytosis of MRSA compared to untreated controls, but AR antagonism reversed this effect, suggesting targeting AR or using 5alpha-reductase inhibitors might aid bacterial clearance in elderly males' chronic wounds.
6 citations
,
June 1981 in “PubMed” This article reviews previously reported cases of whisker hair in individuals who develop severe androgenic alopecia and offers a hypothesis concerning its eventual fate, without presenting new findings.
19 citations
,
May 2006 in “Clinical and Experimental Dermatology” This study identified a novel insertion mutation in the hairless gene that may contribute to the development of congenital atrichia with papular lesions in a Pakistani family.
189 citations
,
July 2000 in “American Journal of Botany” In this study, wild-type Arabidopsis thaliana with responsive root hairs efficiently acquired phosphorus under low-phosphorus conditions compared to mutants, suggesting an adaptive advantage in nutrient-limited environments.
14 citations
,
August 2009 in “Cancer epidemiology” This study found that AHCC significantly reduced alopecia caused by Ara-C in neonatal rats and improved liver function affected by 6-MP and MTX in mice.
1 citations
,
September 2023 In this study, autologous micrografting technology using auricular cartilage was reported to be safe and effective for improving knee function and reducing symptoms in patients with early-stage knee osteoarthritis over six months, but larger studies are needed to confirm these results.
In this study, the researchers found no significant link between CAG repeat numbers in the androgen receptor gene and female pattern hair loss in a Chinese population.
December 2021 in “Benha Journal of Applied Sciences” This study found that high serum alarin levels were linked to both androgenetic alopecia and metabolic syndrome, increasing with the severity of AGA.
1 citations
,
August 2019 in “Journal of pediatric & adolescent gynecology” This report describes a novel AR gene mutation in a female patient, contributing to androgen insensitivity syndrome, and emphasizes its potential impact on genetic counseling.
January 2026 in “Queensland University of Technology” This thesis reviews current therapeutic approaches for ARFID and provides preliminary insights into enhancing treatment and care in Australia, including an evaluation of a pilot dietetic-led cognitive-behavioral therapy intervention.
December 2025 in “Current Issues in Molecular Biology” In this systematic review, animal studies showed that cytarabine causes multi-organ toxicities, notably neurotoxicity, linked to oxidative stress and other mechanisms, though study quality raises concerns about reliability and translation to human outcomes.
1 citations
,
September 2022 in “Rheumatology Advances in Practice” This case report highlights a rare instance of costovertebral arthritis secondary to Systemic Lupus Erythematosus, emphasizing the importance of detailed clinical evaluation and imaging for accurate diagnosis and management of chronic back and chest pain.
This study found that the optimized AR antagonist candidate 39, in a hair-growth mouse model, achieved similar efficacy to pyrilutamide with faster onset and favorable safety, suggesting a promising approach for developing topical treatments with low systemic toxicity for androgenetic alopecia.
January 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This source provides information about the MyUpchar Coupon Code "ARCHANA5," which offers a 60% discount on Ayurvedic medicines, supplements, and wellness products for all users with no minimum purchase required.
30 citations
,
November 2013 in “PLOS ONE” This study found that androgen/androgen receptor signaling accelerates premature senescence in dermal papilla cells, highlighting a potential target for treating androgenetic alopecia.
February 2024 in “Therya notes” In this case report, researchers documented the first instance of alopecia in a bat from Veracruz, México, specifically in an individual of Artibeus jamaicensis, likely caused by a thoracic injury leading to an infection.
October 2025 in “Frontiers in Pharmacology” This review explores the immunopharmacological potential of A. lappa for inflammatory musculoskeletal disorders (IMSDs) but reports no new clinical results, emphasizing the need for standardized research methodologies.