Arhgef3 Regulates Hair Follicle Morphogenesis

    September 2024
    Krithika Kalyanakrishnan, Amy Beaudin, Alexandra Jetté … Mélanie Laurin
    Studysummary This study found that ARHGEF3 is crucial for hair follicle development in mice, as its absence leads to defects in placode compaction and impaired follicle downgrowth, highlighting its role in regulating cell shape rearrangements during embryogenesis.
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    Research cited in this study 10

    1. Mechanical Forces Across Compartments Coordinate Cell Shape and Fate Transitions to Generate Tissue Architecture Nature cell biology · 2024
    2. Molecular and Spatial Landmarks of Early Mouse Skin Development Developmental cell · 2023
    3. Transcriptomic Landscape of Early Hair Follicle and Epidermal Development Cell Reports · 2023
    4. Overactive Wnt5a Signaling Disrupts Hair Follicle Polarity During Mouse Skin Development Development · 2022
    5. The Wave Complex Controls Epidermal Morphogenesis and Proliferation by Suppressing Wnt-Sox9 Signaling The Journal of Cell Biology · 2019
    6. Functional Redundancy of Frizzled 3 and Frizzled 6 in Planar Cell Polarity Control of Mouse Hair Follicles Development · 2018
    7. Planar Cell Polarity-Dependent and Independent Functions in the Emergence of Tissue-Scale Hair Follicle Patterns Developmental Biology · 2017
    8. LHX2 Is a Direct NF-κB Target Gene That Promotes Primary Hair Follicle Placode Down-Growth Development · 2016
    9. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin Developmental cell · 2015
    10. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009