Activation of EGF and FGF Signaling in Developing Mouse Skin Inhibits Hair Follicle Morphogenesis

January 2007

Gavin D. Richardson, Hisham Bazzi, KA Fantauzzo, JM Waters, Heather Crawford, PI Hynd, A.M. Christiano, CA Jahoda

EGF FGF Epidermal Growth Factor Fibroblast Growth Factor hair follicle morphogenesis hair follicle development

TLDR EGF and FGF signaling stops hair follicle development in mice.

The study presented at the Fifth International Congress on Hair Research in 2007 investigated the effects of EGF (Epidermal Growth Factor) and FGF (Fibroblast Growth Factor) signaling on hair follicle development in mice. The researchers found that the activation of these signaling pathways in developing mouse skin inhibited the morphogenesis of hair follicles. This suggested that EGF and FGF played a regulatory role in hair follicle development, potentially providing insights into mechanisms that could be targeted for conditions related to hair growth and loss.

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