Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This paper reviews the genetic aspects of hair disorders and suggests that understanding these genes could advance treatment and diagnosis; it reports no new experimental findings.

This study identified a missense mutation in the keratin 71 gene as the cause of autosomal dominant woolly hair/hypotrichosis in a Japanese family, marking the first human mutation in KRT71 linked to a hair disorder.

The document explains the genetic causes and characteristics of inherited hair disorders.

This study found that FGF18 signaling helps protect hair follicles from radiation damage by maintaining the resting phase and supporting stem cell survival, potentially reducing radiation-induced hair loss.

Genetic mutations cause various hair diseases, and whole genome sequencing may reveal more about these conditions.

This study investigated the effects of Wnt-3a, Wnt-5a, Wnt11, and Wnt-10b on the hair induction-ability of cultured dermal papilla cells.

This study found that dihydrotestosterone alters the balance of Wnt pathway regulators in dermal papilla cells, hindering hair follicle stem cell differentiation and contributing to hair follicle miniaturization.

This study suggests that enhancing endocannabinoid tone with an EMT-inhibitor may have anti-inflammatory effects and slightly increase sebaceous lipid production, which could be beneficial for dry skin conditions.

In this animal study, zinc deficiency in mice was linked to disrupted hair cycles and impaired hair regrowth, which were reversed by zinc supplementation.

This study explored the role of nine specific miRNAs in human hair follicles, revealing significant miRNA/mRNA correlations for miR-24, miR-31, and miR-106a and identifying target genes involved in hair biology.

This study found that a decrease in estradiol levels in women is associated with increased hair shedding due to weakened anchoring of telogen hairs.

This review discusses the genetic origins of autosomal recessive woolly hair with hypotrichosis and reports no clinical results; it highlights the link to homozygous variants in the K25 keratin gene.

A specific gene mutation causes woolly hair and hair loss.

This creative piece by Christa Fairbrother poetically explores the experiences of living with arthritis, with no new research findings reported.

In this study, researchers sequenced the KRT71 gene in 102 dromedary camels to find genetic polymorphisms linked to hair shape, identifying 17 variants but none that fully explained hair shape variations, suggesting other genes may also play a role.

In this study, researchers created a mouse model using CRISPR/Cas9 technology to investigate hypotrichosis simplex and woolly hair, finding that Krt71-knockout mice exhibited curly hair and developed complete hair shedding without immune deficiencies, mimicking conditions seen in humans and potentially aiding future hair disorder research.

This study used the "ARE-Luc" mouse model to visualize androgen receptor activity across various tissues in both male and female mice, highlighting the direct action of androgens outside reproductive organs.

In this study, researchers found that two dominant haplotypes in the EDA2R/AR intergenic region have likely been shaped by demographic changes and selection during human evolution, particularly notable in African and non-African populations.

This study found that AR-007 degrades faster and has a stronger association with hsp70 than AR-014, suggesting it is less stable when bound to the androgen receptor.

A mutation in the KRT74 gene causes tightly curled hair.

A mutation in the KRT25 gene causes a rare hair disorder with thin, woolly hair.

This study found that certain genes were significantly associated with hair length in Inner Mongolia cashmere goats, potentially serving as molecular markers for different hair types.

This article discusses genetic hair disorders in children, outlining diagnostic approaches and highlighting the significance of distinguishing isolated hair defects from those associated with syndromes, but it reports no new clinical results.

This study found a significantly higher frequency of females with six or more fingerprint arches among those with alopecia areata compared to controls.

This study conducted a detailed examination of Terminalia arjuna flowers, suggesting their potential use in establishing botanical standards for identification and standardization in Ayurvedic medicine.

This study investigated AHR signaling's role in skin biology and reported that novel AHR ligands may help restore keratinocyte function and reduce inflammation in skin diseases, suggesting their potential as therapeutic agents.

This study reports that AhR pathway expression is significantly reduced in lymphocytes of alopecia areata patients, suggesting its potential as a diagnostic marker and therapeutic target.

This study found that high-resolution tusk isotope profiles from an African elephant can serve as a proxy for the seasonality of diet and precipitation, helping to reconstruct vegetation and climate in modern and fossil ecosystems.

Reduced AhR signaling in HS tunnels leads to persistent inflammation and microbial imbalance.