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In this study, in silico analysis identified Saponin Re and Emodin as promising candidates for topical treatment of androgenetic alopecia, with Biochanin A having the most favorable safety profile among the tested compounds.

This review discusses arsenic trioxide therapy in acute promyelocytic leukemia and introduces a novel method using hair analysis to monitor arsenic exposure and correlate it with treatment timing, but reports no new clinical results.

This study conducted an in silico evaluation of Korean herbal compounds against key targets involved in androgenetic alopecia, finding Biochanin A, Saponin Re, and Emodin as promising candidates for topical treatments, but highlighting safety and topical formulation challenges.

This study reports that retinol acetate inhibited the pro-oxidant effects of benoxaprofen on polymorphonuclear leucocytes in vitro.

This study identified 92 novel regulators of melanogenesis, highlighting Aldehyde dehydrogenase 1A1 as a potential target for developing new treatments for hyperpigmentation disorders like melasma.

This study found that DGAT1 functions as a key enzyme in murine skin to regulate retinoic acid levels and prevent retinoid toxicity, impacting hair cycle and sensitivity to retinol.

This article discusses the paradoxical effects of valproic acid on hair, reporting both drug-induced hair loss and the potential for hair growth when used topically, but presents no original research findings.

This study found that some synthesized heterocyclic derivatives showed promising 5α-reductase inhibitor, antiviral, and anti-tumor activities, surpassing several reference drugs in effectiveness.

This review article concluded that certain herbal remedies targeting 5-alpha reductase inhibitors may prevent hair loss in androgenetic alopecia by blocking dihydrotestosterone production, although standardizing the concentration of active herbal compounds remains a challenge.

In this systematic review, animal studies showed that cytarabine causes multi-organ toxicities, notably neurotoxicity, linked to oxidative stress and other mechanisms, though study quality raises concerns about reliability and translation to human outcomes.

This study reports that ritlecitinib was prescribed to a diverse group of patients, including adolescents and adults with and without prior treatment for Alopecia Areata, in the first three months after FDA approval, potentially expanding care options for this condition.

In laboratory tests, this study found that a novel natural composition targeting 5-alpha reductase and inflammatory pathways reduced disease-related markers in androgenetic alopecia and benign prostatic hyperplasia more effectively than finasteride.

This article discusses arsenic trioxide as a treatment for refractory or relapsed acute promyelocytic leukemia, noting its effectiveness and manageable side effects.

This review discusses the evidence for using oral medications to treat central serous chorioretinopathy, highlighting eplerenone as having the most support despite a lack of robust efficacy across studies.

This study synthesized and evaluated hydroxycinnamate derivatives for their ability to inhibit human SRD5A1, finding that three compounds showed significant inhibitory activity and low cytotoxicity. Compound 10a notably reduced SRD5A1 protein expression in cells, suggesting potential for nonsteroidal treatment of androgen-related conditions.

This study identified novel 4-Amino-2H-benzo[h]chromen-2-one analogs as potent androgen receptor antagonists that show strong antiproliferative activity against prostate cancer cells, suggesting them as potential lead compounds for therapy development.

This article reviews the current status of oral retinoids in dermatology and reports no new clinical findings.

This study found that arginine deficiency in androgenetic alopecia patients is linked to increased oxidative stress and impaired hair follicle regeneration, with targeted arginine supplementation showing promise as a therapeutic strategy.

This study found that 4-(4-Phenoxybenzoyl)benzoic acid derivatives may act as antioxidants by scavenging certain reactive oxygen species but exhibit prooxidant behavior under specific conditions.

In this study, quercetin and kaempferol, two plant-derived flavonoids, showed stronger binding affinities to JAK3 kinase and moderate binding to 5-alpha reductase type 2, suggesting their potential as natural treatments for androgenetic alopecia, with quercetin demonstrating suitable properties for topical application.

This review discusses plant-derived phytochemicals, such as phytosterols, polyphenols, and fatty acids, as potential alternatives to 5-alpha-reductase inhibitors for prostate cancer treatment, highlighting their promising anti-cancer properties and potentially fewer side effects compared to conventional drugs.

This study found that the leaf extract of Tectona grandis and its major bioactive constituents moderately inhibit the 5α-reductase enzyme, which is linked to androgenetic alopecia, and also possess anti-inflammatory properties, showing promise as dual-action candidates for managing this condition.

This study found that Platycladus orientalis flavonoids may reduce oxidative damage and slow melanin degradation in AGA-affected hair, improving its quality.

This study found that compounds isolated from Osmanthus fragrans var. aurantiacus demonstrated antioxidative and anti-inflammatory activities, potentially offering therapeutic benefits for inflammatory bowel diseases by inhibiting COX-2 and iNOS enzymes and blocking ERK 1/2 MAPK signaling.

In this study, computational analysis identified six molecules, including Jamogenin, as effective in binding to the enzyme 5-alpha reductase (5-AR) from herbal extracts like nettle, saw palmetto, and fenugreek, suggesting potential for hair loss treatments.

This study concluded that 5α-reductase inhibitors were linked to increased sexual dysfunction in men with benign prostatic hyperplasia, but not in men with androgenetic alopecia.

This study identified several compounds from traditional Chinese medicines that may inhibit prostaglandin D2 synthase, potentially providing promising candidates for treating androgenic alopecia with minimal adverse skin reactions.

This article explores the interactions between retinoids and the immune system but reports no new clinical results related to their role in hair cycle control.

This study identified compounds from Laportea bulbifera with potential inhibitory effects on human steroid 5α-reductase 2, suggesting their application in treating benign prostatic hyperplasia.

This study found that ATP may help reduce ribociclib-induced skin damage in rats by mitigating biochemical changes associated with oxidative stress.