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This study found that fluconazole induced early hair follicle resting phase (telogen effluvium) in rats, without changing retinoic acid levels in rats or human patients, suggesting further investigation into fluconazole's hair loss mechanism is needed.

Ritlecitinib is effective and safe for treating alopecia areata, promoting significant hair regrowth.

Low-dose Ritlecitinib may help children with stubborn Alopecia Areata.

This study found that ritlecitinib, approved for alopecia areata in patients aged 12 and older, has an acceptable safety profile with mild to moderate side effects and no increase in serious adverse events compared to placebo.

This study found that a thyroid hormone receptor ẞ subtype-selective thyromimetic was effective in promoting hair growth in mouse and monkey models when applied topically.

This Swedish cohort study found no association between the use of anti-androgenic 5α-reductase inhibitors and improved 5-year all-cause or disease-specific mortality in oesophago-gastric cancer patients, challenging the hypothesis that these drugs enhance survival outcomes.

In this study, a newly designed protein degrader targeting androgen receptors showed promise in reversing hair regrowth inhibition in a mouse model of androgenetic alopecia, suggesting potential as a novel and safe treatment strategy.

In this study, researchers optimized the soft drug AR antagonist 14-P1 to create candidate 39, which demonstrated effective AR antagonism and safety in a hair-growth mouse model, showing similar efficacy to pyrilutamide but with quicker onset and a lower risk of systemic toxicity.

This study found that chronic high dosages of 2-(difluoromethyl)-dl-ornithine caused various toxicities in rats and dogs, with some effects potentially minimized at lower dosages.

In this study, ALR was found to enhance both the proliferation and osteogenic differentiation of mouse bone marrow mesenchymal stem cells, potentially through specific signaling pathways.

This study identified several active compounds in Houttuynia cordata and found that most demonstrated significant antioxidant and acetylcholinesterase inhibitory activity, potentially useful for developing functional tea products.

In this study, real-world data of 31 patients using ritlecitinib for severe alopecia areata showed that 51% achieved significant hair regrowth after one year, with no serious adverse events reported, emphasizing the importance of considering treatment duration for response.

In this study, ritlecitinib, an oral medication approved for adolescents and adults, significantly reduced scalp hair loss and promoted eyebrow and eyelash regrowth in severe alopecia areata patients, with benefits sustained over 48 weeks and generally well-tolerated minor side effects.

This study synthesized and verified the structures of Setipiprant's major and minor metabolites, confirming their regio- and enantioselectivity from earlier proposals in a clinical study.

This study found that among 17 beta-(N-ureylene-N,N'-disubstituted)-4-azasteroids, those with an N'-phenyl moiety were the most effective inhibitors of human type I 5 alpha-reductase.

This study found that all-trans-retinoic acid (ATRA) inhibits mink hair follicle growth by reducing dermal papilla cell proliferation and inducing apoptosis, likely through the TGF-β2/Smad2/3 pathway.

This review discusses the effects of 5ARI drugs on male reproductive parameters, reporting potential decreases in sperm count and motility more significantly in men with pre-existing oligozoospermia, but does not provide fertility outcomes.

This study found that Origanum vulgare extract improved testicular structure and function in mice against finasteride-induced damage by enhancing antioxidant defense and modulating gene expression related to apoptosis.

This review examines the molecular mechanisms by which the proapoptotic protein ARTS inhibits tumorigenesis and discusses prospects for developing drugs that mimic its function, with no new experimental results reported.

This study found that using isotretinoin and acitretin was not linked to a higher risk or severity of COVID-19 in patients undergoing systemic retinoid therapy.

In this study, researchers using molecular docking techniques found that 12-Methoxy carnosic acid from rosemary shows promising potential as a natural inhibitor of the 5 alpha reductase enzyme, which is involved in hair loss, suggesting its efficacy compared to finasteride.

In this study, computational analysis identified six molecules, including Jamogenin, as effective in binding to the enzyme 5-alpha reductase (5-AR) from herbal extracts like nettle, saw palmetto, and fenugreek, suggesting potential for hair loss treatments.

Over 45% of patients with alopecia areata benefit from ritlecitinib, mostly within a year.

This study found that unripe Rubus occidentalis extracts may inhibit benign prostatic hyperplasia development in a rat model by reducing prostate weight and androgen-related gene expression.

In an animal study, researchers observed that a newly synthesized deoxycholic acid derivative showed similar prostate protection effects to finasteride in Wistar rats while being less toxic.