This review analyzed clinical trials and guidelines on 5-α-reductase inhibitors (5-ARIs) and found these drugs significantly improve urinary symptoms in BPH and stabilize hair loss in androgenic alopecia, but may cause sexual dysfunction and gynecomastia.
153 citations
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April 1998 in “Current Biology” This study found that benign tumors with a high risk of malignant progression primarily arise from hair follicle cells when a mutant ras gene is expressed in a specific population of epidermal cells in mice.
1235 citations
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December 2013 in “Nature” This study found that skin fibroblasts in mice arise from two distinct lineages which contribute differently to dermal structure and repair, impacting hair follicle formation during wound healing.
149 citations
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July 2017 in “PLoS Biology” This study found that hair follicle patterning in development may arise from a combination of epidermal prepattern signals and mesenchymal self-organisation, with fibroblast growth factor and bone morphogenetic protein activities playing key roles.
26 citations
,
December 2013 in “Seminars in cell & developmental biology” This article reviews how anatomical differences in skin arise and persist, and suggests the underlying molecular positional code is more complex than apparent, but reports no new research findings.
16 citations
,
October 2014 in “Oral surgery, oral medicine, oral pathology and oral radiology” This study found that keratoacanthoma of the lip likely arises from outer root sheath cells, based on the presence of specific keratin markers and periodic acid-Schiff staining patterns.
4 citations
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March 2005 in “Archives of Pathology & Laboratory Medicine” This case report describes a basal cell carcinoma arising in association with a vellus hair cyst, which the authors note has not been previously reported.
January 2018 in “Springer eBooks” This study discusses how dermatological issues in athletes can arise from or be exacerbated by mechanical trauma, infections, and environmental factors, highlighting the importance of thorough history and examination to differentiate these from other skin conditions.
7 citations
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March 2017 in “Journal of dermatology” This review outlines the clinical and histopathological features that aid in classifying tumors arising from the folliculosebaceous apparatus and reports no new research results.
3 citations
,
March 2019 in “Archives of Plastic Surgery” This study found that hair transplantation effectively corrected altered hairlines and scarring arising from midface-lifting surgery, achieving high patient and physician satisfaction scores without adverse events.
This review clarifies that non-anaemic iron deficiency in non-pregnant premenopausal women often arises from menstrual iron losses and can cause symptoms like hair loss, while in post-menopausal women and adult men, iron deficiency anaemia frequently indicates chronic intestinal bleeding.
1 citations
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July 2023 in “Cureus” This report describes a rare case of pili multigemini, where multiple hair shafts arise from a single follicle, discovered during an examination for folliculitis on a patient's abdomen.
48 citations
,
November 2002 in “Journal of biological chemistry/The Journal of biological chemistry” In this study, researchers found that size polymorphisms in certain hKAP1 genes are linked to the hKAP1.1B and hKAP1.3 genes, arising from intragenic deletions and duplications in Japanese and Caucasian populations.
27 citations
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June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified numerous size polymorphisms in the human ultrahigh sulfur KAP4 genes due to intragenic sequence variations, suggesting these polymorphisms may have arisen through deletions and duplications during evolution.
13 citations
,
August 1995 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that the pH dependency of rat steroid 5α-reductase type II isozyme significantly affects its kinetic properties, including Vmax and Km, suggesting past discrepancies in literature may arise from these pH variances during assays.
2 citations
,
February 2023 in “Urology” This study found that IsoPSA's ability to detect both any prostate cancer and clinically actionable prostate cancer remains unaffected by medications like 5-ARIs and α-blockers, which are commonly used to treat benign prostatic hyperplasia symptoms.
2 citations
,
December 1997 in “Journal of The American Academy of Dermatology” The document concludes that doctors should monitor children's brain development when treating hemangiomas with interferon alfa and consider stopping the treatment if problems arise, while also exploring drugs that might counteract side effects.
December 2025 in “Dermatology Reports” This source describes vitiligo as a chronic condition marked by the loss of skin pigmentation and discusses leukotrichia, a feature affecting 10% to 60% of cases, which arises from melanocyte loss in hair follicles and appears as well-defined white patches on the skin.
This study reports that prostatitis, affecting many men aged 30 to 50, arises from diverse causes, including bacterial infections and pelvic pain syndromes, and requires treatment strategies specific to its type, such as antibiotics and lifestyle changes.
14 citations
,
November 2013 in “Facial Plastic Surgery Clinics of North America” This article discusses the importance of specialized skill in hair restoration surgery and emphasizes the potential impact of both surgeon and assistant errors on the success of the procedure; it reports no new results.
7 citations
,
January 2019 in “Case Reports in Surgery” This case report describes a patient self-injecting facial fillers, highlighting common complications that can mimic oral cancer, leading to diagnostic challenges and economic implications for the National Health Service.
49 citations
,
December 2022 in “Pharmacological Reviews” This review discusses androgen receptor targeting as a potential treatment strategy for triple-negative breast cancer and reports no new experimental outcomes.
33 citations
,
August 2006 in “Journal der Deutschen Dermatologischen Gesellschaft” Pregnancy can cause specific skin conditions that need correct diagnosis and treatment to protect both mother and baby.
24 citations
,
August 2013 in “Facial Plastic Surgery Clinics of North America” This article discusses potential complications in surgical hair restoration and emphasizes the importance of both patient and physician actions in minimizing these risks; it reports no new results.
7 citations
,
April 2014 in “Facial Plastic Surgery Clinics of North America” This review covers complications of neck lift surgery, their causes, ways to reduce them, and management strategies, without offering new clinical findings.
2 citations
,
July 2006 in “European Urology Supplements” 5α-reductase inhibitors can reduce prostate cancer risk but may increase high-grade tumors, needing more research.
This review provides an overview of the etiology, presentation, and diagnosis of steatocystomas, including subtypes and complications, while detailing their history, epidemiology, and management strategies.
January 2024 in “Journal of Natural Remedies” This review identifies recent advances in cholangiocarcinoma research, emphasizing the potential of alkaloids to induce apoptosis and inhibit cellular spread in cancer cell lines, offering insights into future therapeutic compound development.
May 2017 in “InTech eBooks” This review outlines various complications associated with hair transplantation, noting that while most are mild and manageable, serious complications like necrosis can occur if proper care is not taken.
August 2016 in “InTech eBooks” This source highlights the diverse scope of facial plastic and reconstructive surgery, noting the specialty's adaptability to changing trends and ethnic preferences for aesthetic outcomes, without reporting specific study results.