IsoPSA Performance Characteristics Are Unaffected by 5-Alpha Reductase Inhibitors or Alpha-Blockers: Results from the IsoPSA Validation Study

    February 2023 in “ Urology
    Jason Scovell, Mark Stovsky, Alan W. Partin, Yair Lotan, Jack Baniel, Martin Dineen, Jason Hafron, Kannan Manickam, Marc Pliskin, Matthew Wagner, Aimee Kestranek, Eric A. Klein
    TLDR IsoPSA test works accurately even if patients take certain prostate medications.
    The study titled "IsoPSA Performance Characteristics are Unaffected by 5-Alpha Reductase Inhibitors or Alpha-Blockers: Results From the IsoPSA Validation Study" concludes that the diagnostic performance of IsoPSA, a test used for detecting prostate cancer, remains consistent regardless of the use of 5-alpha reductase inhibitors (5-ARI) and alpha-blockers, which are medications commonly prescribed for benign prostatic hyperplasia. This finding is significant as it suggests that patients undergoing treatment with these medications can still rely on IsoPSA for accurate detection of any prostate cancer, including clinically actionable cases, without interference from their medication regimen.
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