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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Hair loss needs more research for better treatments.

Oestrogens are key for bone growth during puberty in both boys and girls.

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Patients with certain skin symptoms and high ANA titers should be monitored for potential systemic lupus.

Minoxidil helps heart function but doesn't improve exercise ability and may cause complications.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Lowering testosterone speeds up wound healing in male mice.

A cluster of sulfur-rich hair protein genes was found on chromosome 17.

Oxidative stress affects hair loss in men with androgenetic alopecia.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.

Genetics and hormones play a role in male and female hair loss, but more research is needed to fully understand it.

Hair follicle regeneration needs special conditions and young cells.

Skin has specialized touch receptors that can tell different sensations apart.

New treatments for male hypogonadism are effective and should be personalized.

Dutasteride and finasteride do not significantly affect bone density, blood fats, or blood production, but slightly lower PSA levels and minimally impact sexual function in healthy young men.

Androgens slow hair growth by altering Wnt signaling in balding cells.

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

Dermal papilla cells help wounds heal better and can potentially grow new hair.

Mint essential oils can kill parasites that cause cystic echinococcosis, with M. pulegium oil being more effective than M. piperita oil.

Kennedy's disease leads to muscle weakness and sensory issues, has no cure but manageable symptoms, and future treatments look promising.

RTA 408 cream protects mice from radiation skin damage.

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

Metformin combined with lifestyle changes improves insulin resistance and reduces testosterone levels in women with PCOS more than lifestyle changes alone.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Bombax ceiba stem bark extracts can lower blood pressure, but high doses can be toxic and lethal.

Hair loss in women may have causes other than hormones.