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Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

Human skin can make serotonin and melatonin, which help protect and maintain it.

Stem cell-derived conditioned medium shows promise for treating various medical conditions but requires standardized production and further validation.

The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

The document provides a method to classify human hair growth stages using a model with human scalp on mice, aiming to standardize hair research.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Periodontal ligament stem cells show promise for regrowing tissues but require more research for safe, effective use.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Male pattern baldness involves hormones and cell signals affecting hair growth.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.

The article concludes that the wool follicle is a valuable model for studying tissue interactions and has potential for genetic improvements in wool production.

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

UV radiation can help sterilize wounds and promote healing but requires careful use to avoid damaging cells.

Activating TRPV3 stops human hair growth.

MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.

Fullerenes show potential in skin care but need more safety research.

Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.

Nutraceuticals may improve skin health and protect against aging, but more research is needed on their optimal use and possible health risks.

New nanocomposites with copper show promise for healing burn wounds and regenerating skin.

Targeted cancer therapies often cause skin reactions, so dermatologists must manage these effects.

Feather growth and regeneration involve complex patterns, stem cells, and evolutionary insights.