research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes
A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.
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research Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor
Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.
research Female Antiandrogens: Significance, Treatment, and Environmental Concerns
Antiandrogens can treat female hormonal conditions, but environmental ones may harm reproductive health.
research The Pathophysiology of Polycystic Ovary Syndrome: Understanding PCOS and Its Endocrinology
The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.
research The Effect of Plasma Rich in Growth Factors on Pattern Hair Loss: A Pilot Study
Treatment with plasma rich in growth factors improved hair density and thickness for hair loss patients.
research Low-Level Light Therapy for Cosmetics and Dermatology
Low-Level Light Therapy is effective for skin rejuvenation, wound healing, and hair growth, with mild side effects.
research A 5α-Reductase Inhibitor, Finasteride, Increases Differentiation and Proliferation of Embryonal Carcinoma Cell-Derived Neural Cells
research Investigational Medications in the Treatment of Alopecia
New treatments for hair loss are being developed using molecular biology.
research Novel Type 1 5a-Reductase Inhibitors With Antiproliferative Potential On LNCaP Cells
New compounds may help treat prostate cancer by reducing cell growth.
research Evidence for Increased 5α-Reductase Activity During Early Childhood in Daughters of Women With Polycystic Ovary Syndrome
Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.
research Assessment of the Usefulness of Dihydrotestosterone in the Diagnostics of Patients with Androgenetic Alopecia
DHT's role in hair loss is important, but measuring its level for diagnosis is questionable.
research Use of Insulin-Sensitizing Agents in Patients With Polycystic Ovary Syndrome
Insulin-sensitizing drugs like metformin can help with ovulation, weight loss, and lower testosterone in some women with PCOS.
research Impact of Nutrition and Exercise on Polycystic Ovarian Syndrome
Eating healthy and exercising can help manage Polycystic Ovarian Syndrome and its related health problems.
research Hormonal Regulation and Systemic Signals of Skin Aging
Hormones affect skin aging, and treatments targeting hormonal balance may improve skin health.
research Impact of Low Dose Finasteride for the Treatment of Androgenic Alopecia on Serum Prostate Specific Antigen Levels in Men Participated in Population-Based Screening for Prostate Cancer
Low dose finasteride causes only minor changes in PSA levels in men over 50 with BPH.
research Neuronal Mimicry as a Resistance Phenotype in Cancer Cells
Low dose finasteride causes only small changes in PSA levels in older men with BPH.
research Does PSADT After Radical Prostatectomy Predict Overall Survival?—A Report from the SEARCH Database Group
Shorter PSADT after prostate surgery is linked to higher risk of death.
research The Hair Growth Promoting Effect of Asiasari Radix Extract and Its Molecular Regulation
Asiasari radix extract promotes hair growth and increases protein synthesis and cell proliferation.
research Efficacy of Autologous Platelet-Rich Plasma Combined With a Non-Cross-Linked Hyaluronic Acid Compound in the Treatment of Female Androgenetic Alopecia: A Retrospective, Case-Series Study
The treatment combining platelet-rich plasma and a non-cross-linked hyaluronic acid compound significantly improved hair density and reduced bald areas in women with androgenetic alopecia, and it's safe with only mild side effects.
research In Search of New Therapeutics: Molecular Aspects of the PCOS Pathophysiology - Genetics, Hormones, Metabolism and Beyond
New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.
research Involvement of Mechanical Stress in Androgenetic Alopecia
research Omega-6 Highly Unsaturated Fatty Acids in Leydig Cells Facilitate Male Sex Hormone Production
Omega-6 fats in certain cells boost male hormone production.
research New Developments in Our Understanding of Acne Pathogenesis and Treatment
We now understand more about what causes acne and this could lead to better, more personalized treatments.
research Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth
Dihydrotestosterone treatment on 2D and 3D-cultured skin cells slows down hair growth by affecting certain genes and could be a potential target for hair loss treatment.
research The Hormonal Background of Hair Loss in Non-Scarring Alopecias
Hormones like androgens, estrogen, thyroid hormones, and stress hormones can contribute to hair loss, and treatments target these hormonal imbalances.
research The Potential Utility of Tirzepatide for the Management of Polycystic Ovary Syndrome
Tirzepatide might help manage PCOS in obese patients but needs more research to confirm safety and effectiveness.
research Melandrium Firmum Extract Promotes Hair Growth by Modulating 5α-Reductase Activity and Gene Expression in C57BL/6J Mice
Melandrium firmum extract helps mice grow hair by blocking a hair loss enzyme and changing hair growth genes.
research Application of Multi-Omics Techniques to Androgenetic Alopecia: Current Status and Perspectives
Multi-omics techniques help understand the molecular causes of androgenetic alopecia.
research Response to Letter Regarding Androgen Receptor PolyQ Alleles and COVID-19
The authors maintain that shorter androgen receptor alleles may lead to milder COVID-19 by positively affecting the immune response, not due to changes in testosterone levels or activity.
research The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function
A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.