Neuronal Mimicry as a Resistance Phenotype in Cancer Cells

The document reports on a study examining the impact of low dose finasteride (1 mg/day), used for the treatment of androgenic alopecia, on serum prostate-specific antigen (PSA) levels in men who participated in population-based screening for prostate cancer in Gunma Prefecture, Japan. Between April 2006 and March 2008, 37,645 men had their PSA levels measured, with 88 men (0.23%) taking finasteride. The study found that changes in PSA levels for men aged over 50 years and with benign prostatic hypertrophy (BPH) were unexpectedly small while taking low dose finasteride. This suggests that aging and existing BPH may result in small changes in serum PSA levels during low dose finasteride treatment. The study involved 66 men who had PSA screening one year prior, with various changes in PSA levels observed, but overall, the mean (median) percent changes of serum PSA levels were relatively minor across different PSA level ranges.