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    Glossary Androgen Suppression

    reducing or blocking male hormones to slow cancer growth

    Androgen Suppression, also known as Androgen Deprivation Therapy (ADT), involves reducing or blocking the action of androgens (male hormones like testosterone) to slow the growth of certain cancers, such as prostate cancer. This can be achieved through medications that inhibit androgen production or through surgical procedures like orchiectomy (removal of the testes).

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    1. Study Answers Some Questions about Androgen Suppression Pre-Radiation, but Not All Oncology Times · 2015
    2. Suppression of FOXO1 activity by SIRT1-mediated deacetylation weakening the intratumoral androgen autocrine function in glioblastoma Cancer Gene Therapy · 2025 · 2 citations
    3. Pantolactams as androgen receptor antagonists for the topical suppression of sebum production Bioorganic & Medicinal Chemistry Letters · 2011 · 5 citations
    4. Rational Design of a Topical Androgen Receptor Antagonist for the Suppression of Sebum Production with Properties Suitable for Follicular Delivery Journal of Medicinal Chemistry · 2010 · 11 citations
    5. Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production Bioorganic & Medicinal Chemistry Letters · 2009 · 7 citations
    6. Bioengineered polyester nanoparticles for the synergistic treatment of androgenic alopecia via the suppression of 5α-reductase and knockdown of androgen receptor Frontiers in Bioengineering and Biotechnology · 2022
    7. Development of fluridil, a topical suppressor of the androgen receptor in androgenetic alopecia Drug Development Research · 2003 · 5 citations
    8. 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production Bioorganic & Medicinal Chemistry Letters · 2009 · 11 citations
    9. Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production Bioorganic & Medicinal Chemistry Letters · 2007 · 11 citations
    10. <i>Arachis hypogaea</i> L. Root Extract Mitigates Testosterone Propionate‐Induced Benign Prostatic Hyperplasia in ICR Mice by Suppressing Inflammation, Androgen Receptors, and Dihydrotestosterone Food Science & Nutrition · 2026
    11. Sex differences in COVID-19: the role of androgens in disease severity and progression Endocrine · 2020 · 121 citations
    12. Androgen excess is the key element in polycystic ovary syndrome Fertility and Sterility · 2003 · 99 citations
    13. Androgens and women's health. PubMed · 1998 · 5 citations
    14. Hyperandrogenic eumenorrheic NON-PCOS women versus women with PCOS after the GnRH-agonist stimulation test preceded by suppression of adrenal steroidogenesis with dexamethasone Journal of Clinical & Translational Endocrinology · 2024 · 1 citations
    15. Treatment of androgen excess in females: Yesterday, today and tomorrow Gynecological Endocrinology · 1997 · 9 citations
    16. Long-Term Suppression of Testosterone After Treatment with a Gonadotropin-Releasing Hormone Agonist in a Woman with a Presumed Testosterone Secreting Ovarian Tumor The Journal of Clinical Endocrinology & Metabolism · 1997 · 19 citations
    17. 7472 Estrogen Monotherapy for Testosterone Suppression in Gender Diverse Patients Journal of the Endocrine Society · 2024
    18. 7472 Estrogen Monotherapy for Testosterone Suppression in Gender Diverse Patients Journal of the Endocrine Society · 2024
    19. Clinical Case Seminar: Postmenopausal androgen excess-challenges in diagnostic work-up and management of ovarian thecosis Clinical Endocrinology · 2017 · 20 citations
    20. Hyaluronic acid-FGF2-derived peptide bioconjugates for suppression of FGFR2 and AR simultaneously as an acne antagonist Journal of nanobiotechnology · 2023 · 6 citations
    21. The Case of the Elusive Androgen Endocrine practice · 2002 · 1 citations
    22. Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia Journal of Investigative Dermatology Symposium Proceedings · 2003 · 78 citations
    23. A new way to restore tumour suppressor function Nature Reviews Drug Discovery · 2013
    24. 410 NON-INVASIVE DIAGNOSIS OF PROSTATE CANCER FROM BODY FLUIDS USING A PANEL OF TUMOR SUPPRESSOR GENES European Urology Supplements · 2011
    25. Treatment of hirsutism and acne in hyperandrogenism 2006 · 54 citations
    26. Hirsutism International journal of clinical practice · 2007 · 37 citations
    27. Treatment of androgenic disorders in women: acne, hirsutism, and alopecia Cleveland Clinic journal of medicine · 1990 · 19 citations
    28. Hirsutism 2005 · 12 citations
    29. UPDATE ON IDIOPATHIC HIRSUTISM: DIAGNOSIS AND TREATMENT Acta Clinica Belgica · 2013 · 6 citations
    30. Ciclosporin-Induced Generalised Hypertrichosis in a Transgender Woman Receiving Testosterone Blockers Cureus · 2026