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Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

Celsr1 is crucial for skin cell alignment, while Celsr2 has little effect on this process.

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

The document recommends a multidisciplinary approach and experience sharing to advance facial feminization surgery as a medical field.

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

Diagnosing sex development disorders requires combining medical history, physical exams, imaging, lab tests, and genetic data.

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

WNT10B is linked to cancer development and affects survival and disease progression in various cancers.

Fox genes are important for hair growth and development in cashmere goats.

Metformin should be used for PCOS mainly in those with glucose intolerance, and has limited benefits for infertility or hirsutism.

Patients with Bohring-Opitz syndrome and ASXL1 mutations need regular kidney ultrasounds to check for tumors.

A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.

The document says menstruation is important for women's health, discusses menstrual disorders, and suggests personalized treatment options.

Early and personalized treatment for hair loss in young people is crucial to prevent permanent damage and should include psychological support.

Young women in West Bengal, India, with PCOS often have estrogen resistance, leptin receptor issues, folate deficiency, T2DM, and acanthosis, commonly linked to obesity.

Certain skin drugs and topical agents, including some natural extracts and fragrances, can cause allergic reactions. Some hair dyes and extensions, as well as minoxidil, a hair growth treatment, can also cause allergies. Botulinum toxin A can effectively reduce sweat but may have temporary side effects.

The document explains the genetic causes and characteristics of inherited hair disorders.

The document emphasizes the importance of correctly identifying and classifying genetic hair disorders to help diagnose related health conditions.

Gonadal dysgenesis, like Turner's and Klinefelter's syndromes, negatively affects bone health, but hormone treatments can help.

The new FDA labeling rules provide more detailed drug safety information for pregnant and breastfeeding women, but more data is needed on the risks of many dermatologic drugs.

Certain skin proteins can form anchoring structures without the protein AMACO.

Group a wide range of chemicals, not just phthalates, for assessing risks to male reproductive health.

Hair growth can be induced by transplanting certain cells, but these cells lose their properties during culturing. The best cell interaction happens in a liquid medium under gravity, and using collagen doesn't help. Future research could focus on using growth factors to stimulate these cells.

A boy with a rare skin condition and kidney disease improved with cyclosporine after steroids failed, suggesting a new treatment approach.

Androgen receptors in the mouse brain may explain cognitive and mood changes in prostate cancer treatment.

Frizzled receptors are essential for various body development processes and maintaining certain body functions.

Whale genes show changes that help them live in water, like less hair and better flippers.

The document concludes that Functional Hypothalamic Amenorrhea should be carefully diagnosed and managed to prevent health complications, using lifestyle changes and specific medications.

Early treatment of acne is crucial to prevent scarring and psychological effects.

Different fish use the same genes to regrow teeth.