December 2008 in “Enzyme and Microbial Technology” New patents include innovations in skin and hair care, disease treatment, plant stress tolerance, and protein purification.
September 2008 in “Pediatric Rheumatology” This study reports that the symptoms and immunological findings in two children with diverse autoimmune-like conditions were ultimately attributed to lysinuric protein intolerance, confirmed by genetic analysis in one child.
April 2007 in “Nature Clinical Practice Urology” TICE salvage chemotherapy is effective for treating germ-cell tumors with poor prognosis.
January 2007 in “Sen'i Gakkaishi” This study found that Mf-rich-fiber in human hair underwent significantly greater degradation by proteases than Ma-rich-fiber, especially when treated with Proteinase K.
January 2007 in “日本看護学会抄録集 成人看護1” This study found that specific residues in human steroid 5alpha-reductase types 1 and 2 influence substrate binding and resistance to the inhibitor Finasteride, with certain substitutions significantly affecting these interactions.
November 2005 in “PubMed” In this study, the researchers successfully cloned and sequenced the hairless gene cDNA of Kunming mice, revealing high conservation and functional significance among various mammalian species.
April 2005 in “Aktuelle Dermatologie” This article reviews advancements in hair cosmetics, including "cosmeceuticals" and new dermocosmetic strategies, and reports no new clinical results.
January 2005 in “Zhongguo yaowu huaxue zazhi” This study successfully developed a synthetic route for finasteride that achieves a 30.6% yield and is suitable for industrial production, avoiding the use of expensive or poisonous reagents.
January 2004 in “Dermatologic Surgery” This study found that storing hair micrografts in DMEM with apoptotic cell death inhibitors improved in vitro hair shaft elongation and reduced apoptosis, potentially enhancing micrograft transplantation outcomes.
September 2002 in “Research Repository (Kingston University London)” This review discusses strategies for treating hormone-dependent prostate diseases and synthesizes a range of potential 5α-reductase inhibitors, but experimental evaluation of these compounds was not completed.
January 2002 in “Agritrop (Cirad)” This study found that mutations in exon 3 of the hr gene are strongly associated with congenital hypotrichosis in Valle del Belice sheep, suggesting a potential genetic link to the disorder.
March 1995 in “Proceedings of the British Society of Animal Science” This review discusses zinc's role in dog metabolism and suggests that zinc from amino acid chelates might be better absorbed than from inorganic sources, but reports no new experimental results.
March 1995 in “Proceedings of the British Society of Animal Science” This review discusses zinc's role in dog nutrition, emphasizing that zinc absorption may be improved when provided as an amino acid chelate rather than an inorganic source, but reports no new results.
July 1994 in “Annals of Pharmacotherapy” Cromolyn sodium's effectiveness for treating asthma in children under 2 is unclear, possibly more beneficial for older children, and further research is needed.
In this study, researchers found that follicular and epidermal transglutaminases are biochemically and immunologically distinct, suggesting the possibility of selectively modifying hair or epidermal proteins.
In this correspondence, the authors reported that patients on a 500-calorie crash diet with rapid weight loss experienced significant hair loss, which began months after dieting and gradually improved.
July 1975 in “Archives of Dermatology” This letter to the editor describes two cases where stopping tetracycline treatment coincided with the disappearance of multiple flat warts on the face in young women.
August 2022 in “International Journal of Health Sciences (IJHS)” In this study of hair loss treatments, patients using a combined regimen of minoxidil, finasteride, and supplements showed significant hair density and caliber improvements within 2-4 months, sustaining these gains for up to two years.
175 citations
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January 1995 in “Birkhäuser Basel eBooks” This review examines the histochemistry and keratinization processes of human hair, exploring the structural roles of keratin proteins, protein chains, and lipids, but offers no new results.
140 citations
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January 2009 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This review discusses the application of liposomes in dermatology, highlighting their therapeutic value for drug stabilization, skin penetration enhancement, and treatment of hair follicle-associated disorders, but reports no new clinical results.
72 citations
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November 2015 in “Multiple Sclerosis and Related Disorders” This study concluded that teriflunomide has a consistent and manageable safety profile, with common mild-to-moderate adverse events and no new safety concerns identified over up to 12 years of treatment.
71 citations
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January 2014 in “Journal of Proteome Research” In this study, distinct metabolic profiles were identified in women with PCOS, suggesting potential biomarkers for diagnosis based on changes in lipid and androgen metabolism.
66 citations
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December 1999 in “Journal of Investigative Dermatology” New mutations in the hairless gene may cause hair loss and affect bone development.
53 citations
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August 2014 in “Cochrane library” This review found no evidence supporting the efficacy of methotrexate for inducing remission in active ulcerative colitis compared to placebo or active comparators.
53 citations
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December 2012 in “Revista da Sociedade Brasileira de Medicina Tropical” In this study, liver transaminase levels and various symptoms persisted in some adult dengue patients even two months after diagnosis.
51 citations
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August 2015 in “Cochrane library” This systematic review reports that there is currently no evidence supporting methotrexate for maintaining remission in ulcerative colitis; further large-scale trials are needed to assess its efficacy and safety.
48 citations
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August 1981 in “American Journal of Veterinary Research” This study demonstrates that glucocorticoid hepatopathy in Beagle dogs led to rapid and lasting clinical, morphologic, and biochemical changes, which may aid in the future diagnosis and prognosis of similar conditions.
47 citations
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November 1966 in “Archives of Dermatology” This study found that trichorrhexis nodosa, a common cause of unexplained hair loss, is primarily caused by trauma rather than a metabolic defect.
44 citations
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September 2020 in “International Journal of Molecular Sciences” This review discusses the disruption of hormonal and metabolic rhythms in polycystic ovary syndrome and explores potential drug targets to address its molecular causes, without providing new clinical results.
40 citations
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February 2002 in “International Journal of Dermatology” In this study, hair damaged by permanent dye showed signs of recovery over time, with near complete restoration to its original state after eight weeks.