Molecular Cloning of Full-Length cDNA Sequences Encoding Hairless Gene in the Kunming Mouse

    November 2005 in “ PubMed ”
    Jintao Zhang, Sheng‐Guo Fang, Chunyao Wang, Chun-Yan Du
    TLDR The hairless gene in Kunming mice is important for hair and skin, and shows genetic variations.
    The study focused on cloning and analyzing the cDNA encoding the hairless (Hr) gene from the Kunming mouse, which is important for hair and skin structure. The full-length cDNA and CDS sequences were successfully cloned and submitted to GenBank, revealing a high degree of conservation across different species, indicating the gene's functional significance. The research identified 4 SNP sites and one deletion mutation in the Hr gene sequences, with two SNPs resulting in amino acid changes, providing new data on genetic variations in the Hr gene.
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