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The alpha-helix was confirmed as a key structure in proteins.

No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

PPAR alpha may help in hair growth and could be a target for treatment.

RXR-alpha is strongly expressed in both normal and psoriatic skin and may help in skin cell differentiation and hair growth.

5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.

Androgenetic alopecia is a common hair loss condition caused by testosterone effects on hair follicles, leading to thinner, shorter, and less pigmented hair, diagnosed using scalp dermoscopy and treated with topical minoxidil, antiandrogen agents, and 5-alpha reductase inhibitors.

A man developed excessive hair growth after treatment with interferon-alpha and ribavirin for hepatitis C.

A woman developed white patches on her skin and curly hair after hepatitis C treatment, likely due to the medication interferon alpha.

Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.

Using 5-alpha-reductase inhibitors, drugs for prostate issues and hair loss, may lead to eye abnormalities in men.

Starting 5-alpha reductase inhibitors does not significantly increase the risk of rhabdomyolysis in older men, but is linked to a higher risk of muscle conditions.

Testosterone undecanoate safely and effectively increased penis size in male children with 5-alpha-reductase deficiency.

Finasteride, when taken daily, lowers dihydrotestosterone levels but doesn't noticeably affect adrenal steroid production, except by blocking the 5 alpha-reductase enzyme.

Men taking 5-alpha reductase inhibitors for prostate issues may be less likely to experience severe COVID-19, but it doesn't prevent ICU admission or death.

Best treatment for Frontal Fibrosing Alopecia is 5-alpha-reductase inhibitors and intralesional corticosteroids.

Certain medications, especially 5-alpha reductase inhibitors, are commonly linked to erectile dysfunction.

5-alpha reductase inhibitors increase the risk of sexual dysfunction in patients treating enlarged prostate but not in those treating hair loss.

The document concludes that the risk of sexual side effects from 5-alpha-reductase inhibitors is low and often temporary, but more research is needed on potential permanent effects.

Intralesional corticosteroids and 5-alpha-reductase inhibitors are the best treatments for frontal fibrosing alopecia.

The G(S) alpha subunit gene may help start hair follicle growth in newborn mice.

Taking 5-alpha reductase inhibitors might be linked to breast cancer in men.

TURP is the best treatment for BPH, but some patients prefer medications like alpha-blockers and finasteride.

Male pattern baldness involves genetics, hormones, and needs better treatments.

More men are getting benign prostatic hyperplasia, and there are many treatments, from medication to surgery, with new methods being developed.

The document concludes that hair is complex, with a detailed growth cycle, structure, and clinical importance, affecting various scientific and medical fields.

The Skin POMC System affects hair growth and skin responses to stress.

Finasteride may cause floppy-iris syndrome during cataract surgery, so check patients' medical history.

Human amniotic membrane helps heal skin wounds faster and with less scarring.

Trichohyalin, a hair follicle protein, has a part with repeating patterns of 23 amino acids.