Differential Expression of a Gene Homologous to a G-Alpha Protein Gene in Neonatal Mouse Skin During Development of Hair Follicles

    January 2001 in “ Journal of dermatological science
    Hexiu Su, Barry R. Palmer, Martin P. Wellby, R. Bickerstaffe, Jonathan G. H. Hickford
    TLDR The G(S) alpha subunit gene may help start hair follicle growth in newborn mice.
    The study investigated gene expression in neonatal mouse skin during hair follicle development, identifying a 248-bp message expressed predominantly on days 2 and 3 after birth, with weaker expression on days 1, 4, and 5. This gene, localized mainly in the dermal papilla, showed 99% identity with the mouse G(S) alpha subunit, which is involved in signal transduction. The timing and location of its expression suggest that the G(S) alpha subunit may play a role in signaling the proliferation of epithelial cells in the follicle bulb, potentially initiating hair follicle growth.
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