A Dispute Between the Cavendish and Caltech: The Emergence and Ubiquity of the Alpha-Helix

February 2020 in “ Oxford University Press eBooks ”

John Meurig Thomas

keratin alpha-helix protein folding myoglobin lysozyme

TLDR The alpha-helix was confirmed as a key structure in proteins.

In 1950, Bragg, Kendrew, and Perutz from the Cavendish Laboratory proposed a model for protein folding, specifically for keratin. This model was quickly challenged by Pauling and Corey from Caltech, who criticized the Cambridge team's proposal and introduced the alpha-helix as a new structural motif for proteins. The alpha-helix's significance and characteristics were outlined, and its validity was later confirmed through X-ray studies of myoglobin and the enzyme lysozyme by Kendrew at the Cavendish Laboratory and Phillips et al. at the DFRL in the United Kingdom.

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