A Retrospective Study of Clinical Outcomes of Alpha-Blocker or Finasteride Monotherapy Followed by Combination Therapy: Determination of the Period of Combination Therapy of Alpha-Blocker and Finasteride

April 2013 in “ International Journal of Clinical Practice ”

Hyungsuk Son, S. W. Cho, Sung Keun Park, J. H. Kang, Changsoo Kim, Hyun-Chul Kim

finasteride alpha-blockers combination therapy Propecia

TLDR Combination therapy for 9+ months maintains symptom improvements after stopping alpha-blockers or finasteride.

This study investigated the outcomes of discontinuing alpha-blockers or finasteride in patients who initially received combination therapy for benign prostatic hyperplasia (BPH). The study found that discontinuation of alpha-blockers or finasteride after combination therapy for more than 6 months maintained improvements in symptoms. The appropriate period of combination therapy was found to be 9 months or longer. The study also showed the superior effect of improvement in symptom scores over alpha-blocker or finasteride monotherapy.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

1707 citations, December 2003 in “The New England Journal of Medicine”

Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.

research Discontinuation of Alpha-Blockade After Initial Treatment With Finasteride and Doxazosin for Bladder Outlet Obstruction

17 citations, February 2001 in “Urologia Internationalis”

Stopping alpha-blocker medication after 6-9 months is safe and effective for most patients with bladder outlet obstruction.

research The Efficacy of Terazosin, Finasteride, or Both in Benign Prostatic Hyperplasia

728 citations, August 1996 in “The New England Journal of Medicine”

Terazosin and finasteride effectively treat BPH, but combining them adds no extra benefit.

Similar Research

5 / 1000+ results

research Epidemiology and Treatment Modalities for the Management of Benign Prostatic Hyperplasia

110 citations, October 2019 in “Translational Andrology and Urology”

More men are getting benign prostatic hyperplasia, and there are many treatments, from medication to surgery, with new methods being developed.

research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

1707 citations, December 2003 in “The New England Journal of Medicine”

Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.

research Sexual Dysfunction Related to Drugs: A Critical Review. Part V: Alpha-Blocker and 5-ARI Drugs

15 citations, November 2015 in “Pharmacopsychiatry”

α-Blockers and 5-ARIs for BPH can cause sexual dysfunction, including erectile and ejaculatory issues.

A Population-Based Nested Case-Control Study: The Use of 5-Alpha-Reductase Inhibitors and the Increased Risk of Osteoporosis Diagnosis in Patients with Benign Prostate Hyperplasia

research A Population-Based Nested Case-Control Study: The Use of 5-Alpha-Reductase Inhibitors and the Increased Risk of Osteoporosis Diagnosis in Patients with Benign Prostate Hyperplasia

22 citations, August 2014 in “Clinical endocrinology”

Taking finasteride for benign prostate hyperplasia may increase the risk of osteoporosis, especially at higher doses.

research Five-Alpha-Reductase Inhibitors for Prostate Cancer Prevention

37 citations, April 2008 in “The Cochrane library”

5-alpha-reductase inhibitors can lower prostate cancer risk but may increase high-grade tumors and cause sexual side effects.

A Retrospective Study of Clinical Outcomes of Alpha-Blocker or Finasteride Monotherapy Followed by Combination Therapy: Determination of the Period of Combination Therapy of Alpha-Blocker and Finasteride

Research cited in this study

research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

research Discontinuation of Alpha-Blockade After Initial Treatment With Finasteride and Doxazosin for Bladder Outlet Obstruction

research The Efficacy of Terazosin, Finasteride, or Both in Benign Prostatic Hyperplasia

Related Community Posts Join

community What Works to Restore Hairloss for Cis-Males? Not Much

community Why is it that low testosterone causes hair loss as well? How can I be balding?

community Bryan Johnson shares information on his hair loss stack

community Finasteride is one of the best decisions I ever made

community Be careful when switching from Finasteride to Dutasteride because for more efficacy.

community Study shows further evidence that finasteride and dutasteride take 12-18 months or more to show significant results. Do NOT give up early

Similar Research

research Epidemiology and Treatment Modalities for the Management of Benign Prostatic Hyperplasia

research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

research Sexual Dysfunction Related to Drugs: A Critical Review. Part V: Alpha-Blocker and 5-ARI Drugs

research A Population-Based Nested Case-Control Study: The Use of 5-Alpha-Reductase Inhibitors and the Increased Risk of Osteoporosis Diagnosis in Patients with Benign Prostate Hyperplasia

research Five-Alpha-Reductase Inhibitors for Prostate Cancer Prevention