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The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

Altered retinoid metabolism in cicatricial alopecia suggests a balanced vitamin A diet may prevent the condition.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Researchers found that most genes affecting drug responses are not fully covered by commercial SNP chips, suggesting the need for more comprehensive tools to optimize drug selection based on genetics.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Activating TLR3 may help produce retinoic acid, important for tissue regeneration.

Sdr16c5 and Sdr16c6 genes regulate a key point in lipid production that affects eye and skin gland function.

Different enzymes are active in different parts of developing mouse organs.

Vitamin A affects hair loss and immune response in alopecia areata.

The right amount of retinoic acid is essential for normal hair growth and development.

Scientists can use engineered microbes to make L-aspartate and related chemicals, but there's still room to improve their efficiency.

The document concludes that the exact way alcohol causes harm to fetal development is unknown, but it significantly affects nutrient transport to the fetus and a safe level of alcohol during pregnancy is not determined.

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

Mice without certain skin enzymes have faster hair growth and bigger eye glands.

Drinking a lot of alcohol increases the risk of prostate cancer and can worsen the condition.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

The same genetic mutation in Sjögren-Larsson syndrome can lead to different levels of severity, suggesting other factors influence the symptoms.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

The document concludes that the technique allows for the detection of LDH activity in various tissues, showing where cells are actively metabolizing glucose.

Spironolactone might lower the chance of getting rosacea.

Natural products in cosmetics are beneficial for skin and hair care with low toxicity.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Finasteride effectively blocks enzyme causing male pattern baldness.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.