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180-210 / 1000+ resultsresearch Atrichia with papular lesions resulting from mutations in the rhesus macaque (Macaca mulatta) hairless gene
This study identified a compound heterozygous mutation in a hairless rhesus macaque, which was associated with skin abnormalities similar to those in hairless mice and humans with APL.
research Assessment of tissue levels of dickkopf-1 in androgenetic alopecia and alopecia areata
This study found elevated tissue levels of DKK-1 in patients with both androgenetic alopecia and alopecia areata compared to controls, suggesting DKK-1 as a potential therapeutic target for these conditions.
research A novel eco-friendly Acinetobacter strain A1-4-2 for bioremediation of aquatic pollutants
This study identified a novel Acinetobacter species, strain A1-4-2, with exceptional biodegradation abilities and low antibiotic resistance, found in diverse environments and potentially useful for ecological restoration by degrading organic pollutants.
research Advances in the mechanism and new therapies of alopecia areata
This study found that the JAK3/TEC kinase inhibitor ritlecitinib was effective and well tolerated in patients aged 12 and older with alopecia areata, providing a potential systemic treatment option for this condition, especially in cases of significant psychosocial impact.
research Atypical pediatric presentation of alopecic and aseptic nodules of the scalp with features of dissecting cellulitis
This case report describes a 9-year-old boy with atypical alopecic and aseptic nodules of the scalp, suggesting possible inclusion within the spectrum of typical AANS and DCS due to its prepubertal onset and facial involvement.
research Alopecia areata incognita: clinical characteristics and use of the Sinclair shedding scale
This study reported that using the Sinclair Shedding Scale and intralesional corticosteroid injections may help diagnose and manage alopecia areata incognita in women experiencing excessive hair shedding without clear diagnostic indicators.
research Adjuvant Scalp Rolling for Patients With Refractory Alopecia Areata
This study suggests that scalp rolling could be a promising and affordable adjuvant treatment for alopecia areata, potentially promoting hair regrowth by enhancing the effects of topical medications and inducing collagen.
research Treatment of chronic alopecia areata with tildrakizumab: an open‐label pilot study
This correspondence about the treatment of chronic alopecia areata with tildrakizumab reports no clinical results; the authors present an open-label pilot study setup.
research LB923 A matched cohort study evaluating the risk of keloid development in alopecia areata patients
Alopecia areata patients are more likely to develop keloids, especially if they also have atopic dermatitis.
research Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence
This study observed that epidermal-specific deletion of aPKCλ in mice disrupts hair follicle stem cell quiescence, leading to altered hair follicle cycling and skin anomalies.
research 0350 Impact of switching janus kinase inhibitors in the treatment of severe alopecia areata
Switching Janus kinase inhibitors helped some patients with severe alopecia areata regrow hair, but insurance issues can worsen the condition.
research AXR3andSHY2interact to regulate root hair development
This study found that different stabilizing mutations in Aux/IAA proteins affect root hair development in Arabidopsis by disrupting the auxin response and suggest a model where the relative abundance of these proteins determines root hair initiation.
research Updated mutational spectrum and genotype-phenotype correlations in ichthyosis patients with ABCA12 pathogenic variants
This study identified 11 previously unreported ABCA12 variants associated with varying severities of autosomal recessive congenital ichthyoses and expanded the phenotype spectrum of ichthyosis linked to these variants.
research Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis
This study found that PDGFA is critical for the proliferation and maintenance of adipocyte stem cells in skin but not other white adipose tissues, highlighting unique regulatory mechanisms in different tissue depots.
research Alopecia universalis with IL-12-RB1 and STAT4 mutations effectively treated with upadacitinib
This article reviews the current FDA-approved treatments for severe pediatric alopecia areata, including the use of Janus kinase inhibitors, but reports no new clinical findings.
research Essential Role for Integrin-Linked Kinase in Melanoblast Colonization of the Skin
In this study, targeted inactivation of the integrin-linked kinase gene in melanoblasts led to defects in cell migration, proliferation, and ability to populate the skin, implicating an integrin-linked kinase-Rac1 connection in melanocyte function.
research ISID1116 – Novel androgen receptor degrader for androgenetic alopecia (AGA) application
In this study, a newly designed protein degrader targeting androgen receptors showed promise in reversing hair regrowth inhibition in a mouse model of androgenetic alopecia, suggesting potential as a novel and safe treatment strategy.
research Prospects of alpha-ketoglutaric acid in the treatment of aging and age-related diseases
This review examines the potential of alpha-ketoglutaric acid as an anti-aging agent and for treating age-related diseases, emphasizing its metabolic, immune, and cosmetic benefits but reports no new clinical trials.
research The genetics of alopecia areata: New approaches, new findings, new treatments
This review summarizes the current genetic research on alopecia areata, including potential new therapeutic strategies, but reports no new clinical findings.
research Evidence on Hidradenitis Suppurativa as an Autoinflammatory Skin Disease
This review examines the role of autoinflammation and immune dysregulation in hidradenitis suppurativa, linking it to genetic factors and autoinflammatory syndromes, but highlights the need for further research to fully understand its pathogenic mechanisms.
research A linear and reticulate crusted keratotic papulopustular eruption: a rare presentation of PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, and Dryness due to Epidermal growth factor receptor inhibitors) complex
A rare skin reaction from cancer treatment was successfully managed with topical treatments and antihistamines.
research Traumatic experiences, dissociative symptoms, and alexithymia in patients with alopecia areata
This study concluded that physical and emotional neglect could significantly contribute to the onset of alopecia areata, with alexithymia and traumatic stress disorder symptoms potentially more common in affected patients.
research Adrenoleukodystrophy: A Rare Case Report
This report highlights a case of adrenoleukodystrophy, a rare disease, diagnosed in a young boy with neuropsychiatric symptoms and Addison's disease, stressing the importance of early diagnosis and genetic counseling.
research Alopecia Areata
This study introduces diagnostic and therapeutic algorithms tailored for tailored management of alopecia areata based on patient-specific factors like age, disease severity, and quality of life.
research Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia
This study reports that the asebia-2J mutation in mice affects sebaceous gland function and leads to hair follicle destruction, offering a model for human scarring alopecias.
research Alefacept for Severe Alopecia Areata
This study found that alefacept showed no significant improvement in treating severe alopecia areata compared to placebo over a 24-week period.
research Alisertib is active as single agent in recurrent atypical teratoid rhabdoid tumors in 4 children
In this study, four children with recurrent atypical teratoid rhabdoid tumors experienced disease stabilization or regression after treatment with alisertib, suggesting its potential role in future trials for this condition.
research Perspectives of Chinese Adult Patients with Alopecia Areata on Janus Kinase Inhibitors Therapy: A Qualitative Analysis Based on Social Media Platforms
This study examined Chinese adult patients' discussions on social media about JAK inhibitors for alopecia areata, highlighting significant interest in these treatments but also concerns about efficacy, relapse, side effects, and the emotional impact of the condition.
research Emerging Topical and Systemic JAK Inhibitors in Dermatology
This review discusses the immunological basis and development of Janus kinase inhibitors for treating skin diseases and reports no new clinical findings.