Prospects of Alpha-Ketoglutaric Acid in the Treatment of Aging and Age-Related Diseases

Alpha-ketoglutaric acid (AKG) is highlighted as a promising agent for treating aging and age-related diseases, with potential applications in dermatology and cosmetology. The analysis of scientific literature over the past 25 years indicates that AKG is involved in various cellular metabolic pathways, serving as an energy donor, precursor of amino acid biosynthesis, and epigenetic regulator. It plays roles in regulating immunity, oxidative stress, and preventing aging. Studies have demonstrated AKG's effectiveness in addressing age-related conditions such as osteoporosis, sarcopenia, neurodegenerative diseases, and metabolic disorders. Additionally, AKG may help reduce facial wrinkles and prevent hair loss, as evidenced by experiments on animals.