127 citations
,
January 2013 in “PLOS ONE” This study found that feeding aged mice a probiotic yogurt induced changes leading to thicker, healthier fur, suggesting a bacteria-triggered interleukin-10-dependent mechanism that mimics signs of youth and reproductive fitness.
59 citations
,
June 2023 in “Nature Aging” This study observed that in aged mouse skin, there was an increase in IL-17-expressing T helper cells, γδ T cells, and innate lymphoid cells, and blocking IL-17 signaling reduced skin inflammation and delayed age-related changes, suggesting it as a potential target to mitigate skin aging.
55 citations
,
June 2006 in “Central European Journal of Public Health” This study observed that Finnish men aged 63 with androgenetic alopecia had higher rates of hypertension and diabetes compared to those with normal hair status.
51 citations
,
November 2011 in “Reproductive Biology and Endocrinology” In this study of reproductive-aged women in Tehran, idiopathic hirsutism and polycystic ovary syndrome were reported to be prevalent, with rates influenced by the screening methods used.
41 citations
,
January 2009 in “International Journal of Trichology” This study found that 58% of men aged 30-50 had androgenic alopecia, with disease severity increasing with age and many being candidates for medical treatment or hair transplantation.
36 citations
,
July 2020 in “American Journal of Infection Control” This study observed that males aged 60 to 79 were admitted and died from COVID-19 more frequently than females, and Latin Americans were more often admitted to the ICU.
31 citations
,
September 2015 in “BJUI” This study found that men aged 50 and older with clinical benign prostatic hyperplasia have a significantly higher prevalence of metabolic syndrome than those without the condition in the UK primary care population.
24 citations
,
August 2005 in “Health and Quality of Life Outcomes” This study observed that women aged 63 with androgenetic alopecia had higher insulin resistance and more role limitations due to physical health compared to those with normal hair.
20 citations
,
January 2021 in “GeroScience” This study found that administering spermidine to aged mice for six months significantly reduced various age-related conditions, including brain, heart, kidney, liver issues, and hair loss, possibly due to decreased telomere attrition.
19 citations
,
April 2015 in “Stem Cells” This study demonstrated that supplementing aged mice with pro-IGF-II improved muscle regeneration by enhancing satellite cell proliferation and reducing adipogenesis, suggesting potential benefits for treating muscle injuries in elderly individuals.
19 citations
,
December 2008 in “Medical Journal of Australia” This study found no significant association between the degree of male-pattern baldness and serum 25-hydroxyvitamin D levels in healthy middle-aged and older men.
12 citations
,
September 2011 in “Archives of Dermatological Research” This study found that policemen aged 40-59 years had a twofold higher prevalence of androgenetic alopecia compared to the general population, with obesity and sunlight exposure contributing to the risk.
11 citations
,
March 2016 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)” This study found that young host mice rejuvenated aged hair follicles after transplantation, while aged host mice did not support hair growth from transplanted follicles.
8 citations
,
July 2022 in “Metabolites” This study found that among middle-aged Korean men, higher serum uric acid levels were associated with a reduced risk of developing lower urinary tract symptoms.
8 citations
,
January 2018 in “Middle East Journal of Digestive Diseases” This case report describes a middle-aged man with alopecia universalis and ulcerative colitis, where hair regrowth occurred following treatment with azathioprine and mesalamine.
6 citations
,
January 2018 in “Pharmacoepidemiology and Drug Safety” In this study, 5-α reductase inhibitors were not significantly linked to increased rhabdomyolysis risk, but they may raise the risk of myopathy and myositis in men aged 66 and older.
5 citations
,
April 2024 in “Animals” This study found that in cashmere goats aged 2 to 7 years, younger goats (2-4 years) produced more cashmere and had a higher population of active secondary hair follicles than older goats (5-7 years), with the latter showing greater oxidative stress.
5 citations
,
April 2016 in “PubMed” This study found that men aged 18-40 with moderate to severe psychosocial impairment from male androgenetic alopecia had a higher risk of sexual dysfunction.
4 citations
,
March 2025 in “The Journal of Dermatology” This study found that in Asian patients aged 12 and older with alopecia areata and significant hair loss, ritlecitinib showed clinical efficacy in improving hair regrowth and eyebrow and eyelash scores over 48 weeks, with an acceptable safety profile observed throughout.
4 citations
,
July 1987 in “Laboratory Animals” This study suggests that female hairless rats aged about 8 weeks offer the most consistent and reliable response in tests evaluating epidermal ornithine decarboxylase activity.
3 citations
,
October 2024 in “Reproductive Sciences” In this study focused on reproductive-aged women assessed for polycystic ovary syndrome under NIH 1990 criteria, only 15.4% with menstrual dysfunction required androgen measurements, and just one-quarter of these showed elevated androgen levels.
3 citations
,
March 2023 in “Journal of Medical Economics” This study found that middle-aged patients, patients in certain geographical regions, and female patients of specific age groups with alopecia areata face higher medical costs, indicating significant financial variability for affected subgroups.
3 citations
,
June 2017 in “The Journal of urology/The journal of urology” This study found that men aged 60 or older with postoperative urinary retention were more likely to undergo bladder outlet procedures within three years.
1 citations
,
November 2024 in “AME Medical Journal” In this case study, scurvy was diagnosed in a middle-aged man on hemodialysis with food insecurity and undetectable vitamin C levels, highlighting the diverse risk factors and persistent challenges in managing vitamin C deficiency among patients with complex medical and social issues.
1 citations
,
May 2024 in “Dermatology Online Journal” In this case study, two middle-aged patients with pruritic scalp erosions were diagnosed with localized pemphigus vulgaris, which resolved without relapse after treatment with low-dose oral prednisone and intralesional triamcinolone acetonide.
1 citations
,
January 2023 in “Annals of Indian Academy of Neurology” This case report describes a middle-aged woman whose scalp condition, cutis verticis gyrata, was an early sign of systemic amyloidosis that went undiagnosed until after she experienced a stroke.
1 citations
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August 2022 in “Медицинский совет” This study reported that among patients aged 19 to 60 who experienced hair loss after COVID-19, a treatment involving a complex drug and peptide lotion led to hair improvement in 92% of cases, with good tolerability and no reported side effects.
1 citations
,
March 2019 in “Journal of Interdisciplinary Medicine” This case report details a middle-aged man with multiple sclerosis who developed difficult-to-evaluate skin reactions after daclizumab treatment, noting only slight improvement with additional therapies.
1 citations
,
June 2018 in “International Journal of Contemporary Pediatrics” This study found that among children aged 1 to 5 with nutritional dermatoses, lower socioeconomic status and dietary fallacies were major factors contributing to poor nutritional status and skin issues.
1 citations
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January 2000 in “Indian Journal of Dermatology” This case report documents a middle-aged female with black piedra on her scalp hair, confirmed through potassium hydroxide examination and fungal culture.