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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Chronic stress in mice changes skin metabolism and gene expression, leading to hair loss.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

Manage women's cholesterol with diet, exercise, and careful treatment choices, especially during pregnancy, PCOS, and menopause.

Most female students at Qassim University know about PCOS, but there are still misunderstandings about it.

Triple Hormonal Blockade (ADT3) can effectively manage prostate cancer but requires careful monitoring for heart risks.

The conclusion is that managing cholesterol is important for women, especially during pregnancy, breastfeeding, and with PCOS, and involves regular screening and careful treatment choices.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

Review determines effective, safe treatments for female hair loss.

Review finds no permanent solution for female hair loss.

Certain genetic variations in the SHBG gene are linked to an increased or decreased risk of PCOS in Mediterranean women.

Women with PCOS may take longer to get pregnant but can have a normal family size, and should manage their overall health to reduce long-term health risks.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

Transdermal testosterone can improve sexual desire in postmenopausal women but lacks long-term safety data and is not FDA-approved for this use.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.

Licorice has many traditional health benefits, but more research is needed to fully support these claims.

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.

Finasteride may improve prostate cancer treatment outcomes.

Finasteride in male rats causes liver and metabolic issues in their offspring.

The document concludes that effective acne treatment requires a personalized combination of therapies and long-term commitment, with retinoids being important for maintenance.

Treatments for melanin disorders exist, but more effective options needed.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

Modulating Cytochrome P450 activity could help develop new skin disease treatments.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.