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SSAT is a key enzyme affecting cell growth and metabolism, with potential but risky use in disease treatment.

Altering SSAT affects fat metabolism and body fat in mice.

Overexpression of SSAT in mice causes hair loss, liver damage, and sensitivity to polyamine analogues.

Overexpressing SSAT in mice makes them highly sensitive to polyamine analogues, causing liver damage and high mortality.

Overexpressing a specific enzyme in mice causes hair loss and female infertility.

Increasing SSAT makes skin more prone to cancer.

Excessive putrescine causes hair loss in transgenic mice by disrupting hair follicle development.

Overexpression of SSAT causes hair loss and skin issues, but reducing putrescine can help.

Hair growth genes work better with more glucose due to changes in gene-regulating markers.

Human keratinocytes do not naturally respond to androgens.

Drug metabolism affects how long a drug works, its interactions, activation, and toxicity, and is influenced by genetics, diet, illness, and other drugs.

Acetylcholine receptors might be involved in the development of acne inversa and smoking could worsen the condition.

Human skin can make serotonin and melatonin.

Overexpressing SSAT enzyme reduces prostate tumor growth in mice.

Mouse skin can produce and process serotonin, with variations depending on hair cycle, body location, and mouse strain.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The TGM3 gene's promoter region is key for skin and hair cell function and may aid gene therapy.

Putting α-methylspermidine on mouse skin can start hair growth.

The commentary explains that a balance of HR protein and putrescine is important for normal hair growth.

Melatonin receptors, found in many body parts, can help treat various diseases like depression and diabetes due to their effects on inflammation, tumor progression, sleep disorders, and body mass regulation.

MOF controls key genes for skin development by regulating mitochondrial and ciliary functions.

Nestin identifies specific progenitor cells in hair follicles that can become outer root sheath cells.

MOF controls skin development by regulating genes for mitochondria and cilia.

Nestin-expressing cells turn into a specific type of skin cell in hair follicles during development and in adults.

Nestin marks cells that can become a specific type of skin cell in hair follicles of both developing and adult mice.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

The paper concludes that understanding melanocyte development can help in insights into skin diseases and melanoma diversity.

Human skin can make serotonin and melatonin, which help protect and maintain it.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.