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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

4-(4-Phenoxybenzoyl)benzoic acid derivatives can both increase and decrease certain types of reactive oxygen species, and may be relevant to hair loss.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Compounds from Angelica koreana roots, especially osthenol, could be effective for treating conditions like prostate disease and hair loss.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

New compounds may help treat prostate cancer by reducing cell growth.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Plant-based remedies may treat hair loss by reducing inflammation and improving insulin resistance.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Dutasteride effectively treats enlarged prostate, reduces prostate cancer risk, and promotes hair regrowth with few side effects.

Androgens, like DHT, affect hair growth and treatments like finasteride may help.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

Herbal extracts may help hair grow and could be an alternative to synthetic hair loss treatments.

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

The document concludes that hair loss is influenced by genetics and other factors, and while treatments like finasteride can help, they have limitations and side effects.

Low doses of BPA can increase prostate growth and change hormone levels in adult rats.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

AGA, a common hair loss, is caused by genetics, hormones, age, and environmental factors.

Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.

Finasteride effectively treats baldness but may cause sexual side effects.

The document suggests more research is needed to understand the link between baldness and prostate cancer.

Longer TA repeats in the SRD5A2 gene may increase acne risk in Chinese people.

Various medicinal plants like Polygonum multiflorum, Red ginseng extract, and Zizyphus jujuba can potentially treat hair loss, offering benefits like low cost and multiple ways of working. Other effective natural substances include Pygeum africanum, Seneroa, Urtica dioica, and more.