Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that terpene compound concentrations in coniferous tree leaves were generally highest in spring and summer, suggesting these seasons are most effective for extracting essential oils.

This case report study presents two instances of post-finasteride syndrome, highlighting the persistence of sexual adverse effects despite discontinuation of the drug, and underscores the need for increased awareness and understanding of this condition.

In this study, researchers successfully synthesized a rigid 3a-arylhexahydropentalene-1,6-dione from the easily accessible starting material cyclopent-2-en-1-one, highlighting a structural motif common in natural products and pharmaceuticals.

The researchers reported that compounds 11 to 13 derived from Westphalen-type steroids showed strong antiandrogenic activity in vivo, though their effects could not be attributed to 5α-reductase inhibition or androgen receptor binding.

This study reported that newly synthesized phenanthridin-3-one derivatives effectively inhibit human steroid 5-α-reductase.

In this study, researchers isolated new compounds from the plant *Calanthe cardioglossa* and found that five of these compounds, particularly calancardin B, significantly reduced TNF-α levels in immune cells relevant to multiple sclerosis, suggesting potential for immunomodulatory effects.

A new antiandrogen compound was made and its detailed three-dimensional shape was described.

In this study, researchers used genomic, metabolomic, and transcriptomic methods to explore the biosynthetic capabilities of S. longa, aiming to better understand the species and lay the groundwork for future studies on the biosynthesis and therapeutic use of cepharanthine and similar alkaloids.

This paper discusses various toxicological properties of diphenyl cresyl phosphate, highlighting its low acute toxicity, potential neurotoxicity linked to o-cresyl phosphate content, and the lack of data for inhalation exposure, but presents no new experimental findings.

This study found that hypaphorine alters cytoskeletal organization in Eucalyptus globulus root hairs, contributing to reduced root hair elongation by possibly disrupting vesicle delivery needed for growth.

This study observed that new trienone compounds consistently showed higher 5alpha-reductase inhibitory activity compared to corresponding dienones across various biological models.

This study found that several new pregnane derivatives, especially steroids 16 and 19, demonstrated higher antiandrogenic activity on male hamster models than the commonly used finasteride.

This review discusses the historical development, mechanisms of action, and potential new clinical applications of the drug cepharanthine, highlighting its multi-faceted pharmacological properties; it reports no new clinical results.

A new compound was made that might help treat diseases related to male hormones.

This study found that exposure to heated phenyl glycidyl ether vapor caused alopecia and skin lesions in rats but not in dogs.

This study found that the AabHLH112 transcription factor positively regulates the biosynthesis of β-caryophyllene, epi-cedrol, and β-farnesene in Artemisia annua.

This study found that cepharanthine and its structural analogues may stimulate hair growth by promoting the proliferation of human dermal papilla cells and increasing VEGF expression in vitro.

This study found that calanthoside, a compound isolated from Calanthe species, promotes the proliferation of human hair follicle dermal papilla cells more effectively than minoxidil.

This study found that Phyllanthus urinaria extract displayed significant anti-alopecia properties in a mouse model, showing potential as an anti-5α-reductase agent for androgenic hair loss.

This study describes the molecular conformation and intermolecular interactions in the crystalline structure of the compound C24H31BrO4.

Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.

This study suggests that low phosphorus and ethylene may influence root hair density through separate pathways, with ethylene manipulation affecting root hair growth in Arabidopsis thaliana.

This study found that indole glycosides from Calanthe discolor Lindl. can significantly promote the proliferation of human hair follicle dermal papilla cells, potentially through upregulating specific growth factors.

This study found that two synthesized androst-4-ene-3-one derivatives, 6f and 6g, exhibited stronger anti-proliferative effects than common drugs on prostate cancer cell lines, with low toxicity to rat cells.

This study investigated the phytochemicals in Phyla nodiflora leaf extracts and identified n-Hexadecanoic acid, stigmasterol, and beta-sitosterol as promising drug candidates for diabetes, alopecia, cancer, and anti-diuresis, advocating further research into these compounds.

This research outlines a chemical synthesis process for Finasteride, detailing the conversion of pregnadienolone acetate through various chemical reactions and modifications.

This study found that GhPLDα1 in upland cotton may be involved in fiber development, correlating with increased hydrogen peroxide and cellulose biosynthesis during secondary cell wall thickening.

This study reports the first identification of 'Candidatus Phytoplasma aurantifolia' in the invasive weed Eclipta prostrata in Taiwan, linked to symptoms such as branch proliferation and phyllody.

In this study, researchers introduced a visible-light-mediated intramolecular cycloaddition method that selectively forms 6-azabicyclo[3.1.1]heptanes, suggesting these structures could offer promising new scaffolds for drug discovery and medicinal chemistry.