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5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

Natural 5AR inhibitors effectively improve mild to moderate hair loss in men.

Finasteride, when given in high oral doses to pregnant monkeys, caused genital abnormalities in male fetuses, but not in female fetuses or those exposed to intravenous finasteride.

Plant extracts effectively reduce hair loss and increase growth, offering a safe alternative treatment.

Finasteride improves hair density and thickness in women with hair loss.

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.

Spironolactone reduces the enzyme activity that converts testosterone to DHT, helping treat excessive hair growth in women.

Equisetum debile extract, especially the ethyl acetate type, may be a promising natural ingredient for anti-hair loss products.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

A new drug, dutasteride, is at least as effective as the older drug, finasteride, for treating enlarged prostate and may have additional uses.

The study found that the enzyme linked to acne is present in the same areas of both acne-affected and normal skin.

5-α-reductase inhibitors reduce prostate cancer risk but may cause sexual dysfunction and don't affect high-grade tumor or death rates.

Testosterone can build muscle and bone without enlarging the prostate when a specific enzyme is blocked.

DPCP helps treat severe hair loss, but 5% minoxidil doesn't add benefits.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

Some men's prostate tissues have low enzyme levels due to genetic changes, possibly affecting treatment for prostate enlargement.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.

5-alpha-reductase inhibitors may reduce COVID-19 symptoms in bald males.

The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

The exact cause of increased 5α-reductase activity leading to hirsutism in women is still unknown.

Long-term use of a certain medication can worsen erectile function in aged rats by damaging penile muscle cells.

Curcuma aeruginosa extract combined with minoxidil effectively treats male-pattern baldness.

Finasteride and minoxidil together promote hair growth better than either alone.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.