Search

everythinglearnresearchcommunity

for

Search:↓

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.

The document concludes that accurate measurement of serum androgens is crucial for diagnosing hyperandrogenism.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Genetic variations greatly affect individual metabolism and can impact health and disease risk.

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

Finasteride reduces prostate cancer risk but may increase high-grade cancer chances.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

Finasteride treatment can decrease certain steroids and increase others, possibly leading to depression symptoms in some cases.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

New tests detect finasteride and dutasteride in urine quickly and easily.

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Men with male-pattern baldness have higher levels of certain testosterone metabolites and may have more active androgen metabolism.

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.

A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.

5α-reductase inhibitors can interfere with doping tests by masking banned substances.

People with hair loss may have different levels of certain hormones due to changes in hormone processing.

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

The activity of a specific rat enzyme in the prostate and epididymis is highly dependent on the acidity level.

The exact cause of increased 5α-reductase activity leading to hirsutism in women is still unknown.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

Proscar (finasteride) blocks 5α-reductase in sea urchin ovaries and testes, suggesting potential treatment for androgen-related conditions.

Finasteride affects prostate weights and pituitary activity differently with age.