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This review examines the development and challenges of using PROTACs, a targeted protein degradation strategy, to treat cancer by degrading specific proteins like PARPs and GPX4, highlighting issues such as target diversification and bioavailability.

In this study, researchers found that adult tinea capitis in Korea shows unique epidemiological and clinical features compared to children, which may lead to misdiagnosis or delayed diagnosis.

This study found that female pattern hair loss in Western India is often associated with metabolic syndrome, which correlates with earlier onset and increased severity.

In this study, terbinafine reached high concentrations in stratum corneum and sebum after oral administration, with drug levels remaining above fungicidal concentrations for over three weeks.

This study analyzing 40 pediatric patients treated for head and neck sarcomas in a Polish clinic from 2015-2022 found rhabdomyosarcoma was the most common type, requiring complex oncological and surgical treatment, often involving reconstructive techniques.

Some medications caused temporary health issues that improved after stopping the drugs, but two patients died from liver problems linked to carbamazepine.

This study reports the crystal structure and geometric parameters of a modified Finasteride derivative, highlighting significant differences in dihedral angles compared to its solvated analog and computational models.

This article discusses the roles of epidermal stem cells in maintaining skin homeostasis and highlights how deregulation in signaling pathways may lead to cancer, but it reports no new experimental results.

Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.

This study observed that calcifying epithelioma of Malherbe is composed of tumor cells that differentiate into both hair cortex and outer root sheath, supporting its hair follicle origin.

This study identified that the Wave complex proteins ABI1 and Wave2 play a crucial role in regulating epidermal shape and growth during skin development, notably influencing SOX9 expression and Wnt signaling pathways.

Minoxidil can cause deadly skin reaction; monitor patients closely.

This review discusses various stem cell compartments in adult murine and human epidermis, examining their expressed markers and characterization assays, and reports no new experimental results.

This review highlights recent advances in understanding how the extracellular matrix regulates epidermal stem cell fate, emphasizing the importance of the hair follicle stem cell niche, but reports no new empirical findings.

This study found that ablating centrosomes in developing epidermis alters keratinocyte division without majorly affecting differentiation, suggesting early epidermal development is driven by high proliferation and cell delamination.

This study found that manipulating Wnt signaling pathways in cutaneous wounds can induce skin structures resembling regeneration, suggesting a potential role for Wnt signals in restoring skin architecture during wound healing.

In this study, deleting the Igf1 receptor in specific skin cells of mice affected hair follicle cycling but not overall skin health, suggesting Igf1r's role in hair cycle regulation through Bmp-4 activation.

This study observed that the expression of certain keratins during human epidermal development marks the tissue's commitment to stratification and keratinization processes.

This article provides contact information for Bruce A. Morgan and features no new research findings.

This review discusses the range of long-term complications, including mucocutaneous, ocular, and psychological sequelae, for survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis, but reports no new clinical results.

In a transgenic mouse model, this study found that overexpression of keratin 16 in skin keratinocytes led to hyperkeratosis and increased EGF receptor signaling, altering skin cell behavior and structure.

This review discusses the role of Hedgehog signaling in epidermal and hair follicle development and its involvement in basal cell carcinoma, without reporting new empirical findings.

This study used electron microscopy to identify a distinct dendritic cell in the human epidermis, similar to the melanocyte, with unique structural features and variable melanin content.

This article reviews the role of polarity proteins in epidermal morphogenesis and homeostasis and discusses how their alteration may contribute to skin disease, but reports no new experimental findings.

This review discusses stem cell therapy as a promising treatment for epidermolysis bullosa, highlighting preliminary successes in treating skin lesions but noting the need for further research on effectiveness and safety.

This study reported no Cx30 expression in normal interfollicular human epidermis and minimal expression in some skin structures, with faint detection in porokeratosis of Mibelli patient skin.

Human melanocytes in skin and hair follicles don't express keratin 16 or 6 naturally.

In this study, the introduction of autofibroblasts into ischemic wounds was found to be slightly less favorable for regenerative histogenesis compared to a dermal equivalent with heterofibroblasts, with minor differences in epidermis thickness, collagen fiber area, and blood vessel area.

This study found that testosterone significantly stimulated the proliferation of outer root sheath cells when co-cultured with beard or axillary dermal papilla cells, but not with cells from occipital scalp hair follicles.

This case report describes a 65-year-old man diagnosed with a trichofolliculoma, a benign tumor originating from hair follicles, which appeared as a persistent pore on his cheek.