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270-300 / 1000+ resultsresearch Human Peptidylarginine Deiminase Type III: Molecular Cloning and Nucleotide Sequence of the cDNA, Properties of the Recombinant Enzyme, and Immunohistochemical Localization in Human Skin
PAD3 plays a key role in hair and skin protein structure and may be linked to skin diseases.
![The Role of Benign Prostatic Hyperplasia Treatments in Ejaculatory Dysfunction](/images/research/ecfdc3d1-7c39-4fb3-8b0c-145049ab760e/small/17143.jpg)
research The Role of Benign Prostatic Hyperplasia Treatments in Ejaculatory Dysfunction
Treatments for enlarged prostate can cause problems with ejaculation, and less invasive options might preserve sexual function better.
research Frontal Fibrosing Alopecia: An Example of Disrupted Aryl Hydrocarbon Receptor-Mediated Immunological Homeostasis in the Skin?
Excessive sun protection might cause frontal fibrosing alopecia by disrupting skin immune balance.
![Selection Signatures for Fiber Production in Commercial Species: A Review](/images/research/11f86002-2c7f-4135-b97c-cb29e331c959/small/19147.jpg)
research Selection Signatures for Fiber Production in Commercial Species: A Review
Genomic research can help improve the quality and production of natural fibers in animals.
![Amino Acids Oral Treatment for the Amelioration of Skin, Hair, and Nails Conditions: An Open-Label Study](/images/research/53efc7e2-f693-42c6-8737-9cd74fed5258/small/26984.jpg)
research Amino Acids Oral Treatment for the Amelioration of Skin, Hair, and Nails Conditions: An Open-Label Study
Taking an amino acid supplement improved skin, hair, and nail health in women.
![Recent Advances in Highly-Efficient Near Infrared OLED Emitters](/images/research/ccf44868-c6eb-44dd-b513-bd16cd61dcd9/small/26821.jpg)
research Recent Advances in Highly-Efficient Near Infrared OLED Emitters
New near-infrared OLED emitters are more efficient, especially platinum(II) complexes, and have promising applications like hair growth treatment.
![Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors](/images/research/8bcbca37-4db9-4227-b504-4b77308bb53a/small/15733.jpg)
research Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors
Blocking cholesterol production may help control hair loss in Primary Cicatricial Alopecia by affecting key regulators.
![[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs](/images/research/4eb017dc-711d-4926-bcd0-c3b8f48e3a99/small/19974.jpg)
research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs
ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.
![Synthesis of N-Substituted 3-Oxo-17b-Carboxamide-4-Aza-5a-Androstanes and the Tautomerism of 3-Oxo-4-Aza-5-Androstenes](/images/research/c7c6269c-096c-4495-a954-6ffab4ccd99b/small/15586.jpg)
research Synthesis of N-Substituted 3-Oxo-17b-Carboxamide-4-Aza-5a-Androstanes and the Tautomerism of 3-Oxo-4-Aza-5-Androstenes
Researchers made two new compounds that could be used for medicine.
![Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens](/images/research/eef64229-a318-4401-9078-f2eacee058ec/small/21068.jpg)
research Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens
The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.
![Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase](/images/research/d19df8a7-8de6-4430-8a0d-4ffa1f502985/small/15608.jpg)
research Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase
New compounds were made that effectively block a specific enzyme related to androgen conditions.
![In Vitro and In Vivo Effects of 17β-N-(4-Phenylcarbamoyl) Androst-4-en-3-one Derivatives as 5α-Reductase Inhibitors on Androgen-Dependent Glands](/images/research/e7c0a3ce-09ac-4c47-9e06-f91c86a222b9/small/11559.jpg)
research In Vitro and In Vivo Effects of 17β-N-(4-Phenylcarbamoyl) Androst-4-en-3-one Derivatives as 5α-Reductase Inhibitors on Androgen-Dependent Glands
Three compounds were found to inhibit a prostate disease-related enzyme and reduce prostate size more effectively than the current treatment, suggesting they could be used for treating benign prostatic hyperplasia.
![Patent Evaluation: Δ-4,6-Steroids as Potent 5α-Reductase Inhibitors](/images/research/12d5ebe3-2090-4394-b918-8c5199fa0e42/small/21114.jpg)
research Patent Evaluation: Δ-4,6-Steroids as Potent 5α-Reductase Inhibitors
New steroids were patented as effective for treating acne, hair loss, and other conditions related to hormones.
![Structure-Guided Manipulation of the Regioselectivity of the Cyclosporine A Hydroxylase CYP-sb21 from Sebekia Benihana](/images/research/83bdb567-ae34-479a-b59d-b67ab8d62c34/small/22889.jpg)
research Structure-Guided Manipulation of the Regioselectivity of the Cyclosporine A Hydroxylase CYP-sb21 from Sebekia Benihana
Scientists improved an enzyme to better produce a hair growth-promoting chemical from an immunosuppressant.
![Treatment Options for Alopecia: An Update, Looking to the Future](/images/research/9f958284-2f11-44c0-82d4-c642de399d5b/small/26027.jpg)
research Treatment Options for Alopecia: An Update, Looking to the Future
The document concludes that there are various treatments for different types of alopecia, but more research is needed for evidence-based treatments.
![Repair of Damaged Hair Protein Fiber by Jointly Using Transglutaminase and Keratin](/images/research/e57917a5-48ba-480b-bffe-c85c9af65c8b/small/30739.jpg)
research Repair of Damaged Hair Protein Fiber by Jointly Using Transglutaminase and Keratin
Using an enzyme and keratin treatment can significantly repair and strengthen damaged hair.
![Sulfation of Minoxidil by Liver Sulfotransferase](/images/research/5cea6420-bf9e-4cdc-a85a-639b98635585/small/1812.jpg)
research Sulfation of Minoxidil by Liver Sulfotransferase
Liver enzyme helps minoxidil work better for blood vessel relaxation.
![Comparison of Metformin and N-Acetylcysteine on Metabolic Parameters in Women with Polycystic Ovarian Syndrome](/images/research/b56ba3ce-3f9b-4109-aed2-1022686c5f48/small/13821.jpg)
research Comparison of Metformin and N-Acetylcysteine on Metabolic Parameters in Women with Polycystic Ovarian Syndrome
N-acetylcysteine was more effective and had fewer side effects than metformin for improving insulin resistance in women with PCOS.
![Neurotrophin-4 Modulates the Mechanotransducer Cav3.2 T-Type Calcium Current in Mice Down-Hair Neurons](/images/research/a89defe7-6b2a-494d-9925-69b5f60a90f4/small/36013.jpg)
research Neurotrophin-4 Modulates the Mechanotransducer Cav3.2 T-Type Calcium Current in Mice Down-Hair Neurons
Neurotrophin-4 increases calcium current in specific mouse neurons through the PI3K pathway.
![The Evaluation of IL-4 Intron 3 VNTR and TNF-α (rs1799964) Gene Polymorphisms in Egyptian Patients with Alopecia Areata: A Case-Control Study](/images/research/2718cef6-4054-4b31-88fc-a26b08debe31/small/36899.jpg)
research The Evaluation of IL-4 Intron 3 VNTR and TNF-α (rs1799964) Gene Polymorphisms in Egyptian Patients with Alopecia Areata: A Case-Control Study
These specific gene polymorphisms are not linked to Alopecia Areata in Egyptians.
![Fatigue, Alopecia, and Stomatitis Among Patients With Breast Cancer Receiving Cyclin-Dependent Kinase 4 and 6 Inhibitors: A Systematic Review and Meta-Analysis](/images/research/946dc1b9-f4bf-4d84-837c-50a43c7e8f50/small/24160.jpg)
research Fatigue, Alopecia, and Stomatitis Among Patients With Breast Cancer Receiving Cyclin-Dependent Kinase 4 and 6 Inhibitors: A Systematic Review and Meta-Analysis
Breast cancer patients taking CDK4/6 inhibitors are more likely to experience fatigue, hair loss, and mouth sores.
![Synthesis, Anticancer, and Molecular Docking Studies of 2-(4-Chlorophenyl)-5-Aryl-1,3,4-Oxadiazole Analogues](/images/research/a7ba2bde-99be-4e12-ac44-1fadc4324699/small/22652.jpg)
research Synthesis, Anticancer, and Molecular Docking Studies of 2-(4-Chlorophenyl)-5-Aryl-1,3,4-Oxadiazole Analogues
The compound 4c showed strong potential as an anticancer agent.
research Caffeic Acid N-[3,5-Bis(Trifluoromethyl)Phenyl] Amide as a Non-Steroidal Inhibitor for Steroid 5α-Reductase Type 1 Using a Human Keratinocyte Cell-Based Assay and Molecular Dynamics
research Binding Interactions of Keratin-Based Hair Fiber Extract to Gold, Keratin, and BMP-2
Keratin from hair binds well to gold and BMP-2, useful for bone repair.
![The Effects of the COVID-19 Pandemic on the Dermatology Outpatient Clinic of Aydın Adnan Menderes University Hospital](/images/research/3464ba46-0a1d-42ea-8f26-2bfe78790702/small/36631.jpg)
research The Effects of the COVID-19 Pandemic on the Dermatology Outpatient Clinic of Aydın Adnan Menderes University Hospital
COVID-19 reduced dermatology visits by 30.4%, with more male patients and increased cases of psoriasis, bullous diseases, and melanoma.
![Radioimmunoassay of Minoxidil in Human Serum](/images/research/4fb95f9f-e4f2-4123-aa5d-daec96c3b36f/small/1774.jpg)
research Radioimmunoassay of Minoxidil in Human Serum
Minoxidil levels measured in human blood.
![Canine Dermatophytosis Caused by Trichophyton Rubrum: Case Report](/images/research/38529522-d40e-491f-bfd7-a42aa23a62b2/small/27392.jpg)
research Canine Dermatophytosis Caused by Trichophyton Rubrum: Case Report
A dog with skin lesions was successfully treated for a human-type fungal infection.
![Extract of Allium Tuberosum Rottler Ex Spreng Promoted Hair Growth Through Regulating the Expression of IGF-1](/images/research/63e7756b-de72-44f5-bf29-019430bd43b9/small/23085.jpg)
research Extract of Allium Tuberosum Rottler Ex Spreng Promoted Hair Growth Through Regulating the Expression of IGF-1
Garlic chive extract helped mice grow more hair by increasing a specific growth factor.
![Selective Induction of Apoptosis in the Hamster Flank Sebaceous Gland Organ by a Topical Liposome 5-Alpha-Reductase Inhibitor: A Treatment Strategy for Acne](/images/research/ca170f21-a81d-4e61-b564-f26225cdad24/small/14863.jpg)
research Selective Induction of Apoptosis in the Hamster Flank Sebaceous Gland Organ by a Topical Liposome 5-Alpha-Reductase Inhibitor: A Treatment Strategy for Acne
A topical treatment safely and effectively reduced acne by causing targeted cell death in sebaceous glands without side effects.