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Vitamin A is important for healthy skin and hair, influencing hair growth and skin healing, but UV light reduces its levels.

Leptin-deficient mice, used as a model for Type 2 Diabetes, have delayed wound healing due to impaired contraction and other dysfunctional cellular responses.

Eating too much or too little vitamin A can cause hair loss.

Various medicinal plants like Polygonum multiflorum, Red ginseng extract, and Zizyphus jujuba can potentially treat hair loss, offering benefits like low cost and multiple ways of working. Other effective natural substances include Pygeum africanum, Seneroa, Urtica dioica, and more.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Hair growth is influenced by interactions between skin layers, growth factors, and hormones, but the exact mechanisms are not fully understood.

ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.

Botanicals like green tea extract show potential for hair growth, but more research is needed.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Testosterone may slow down wound healing and increase inflammation.

Men with baldness have higher levels of specific proteins, suggesting local hormone production may play a role in hair loss.

Glioblastoma cells can make androgens, which might help the tumor grow.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

The document highlights various patents for new compounds with potential treatments for multiple diseases, including cancer, hormonal disorders, and diabetes.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Sulforaphane may help with hair growth by breaking down a hormone that causes hair loss.

The enzyme that changes testosterone to a stronger form is mostly found in the part of the hair follicle called the dermal papilla.

Increased HSD11B1 enzyme expression is linked to higher body fat and insulin resistance.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

5-alpha reductase inhibitors can cause sexual, neurologic, endocrine, and cardiovascular side effects, but these are rare and usually stop after ending treatment.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

The human type II 5α-reductase gene has a specific structure important for understanding certain medical conditions.

Ketoconazole reduced hair growth and improved acne in women, but caused side effects needing careful monitoring.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.