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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.

Topical finasteride with EGCG or TA improves drug release and dermal uptake, potentially treating hair loss effectively.

Saw palmetto extract can block the enzyme that converts testosterone in pig prostate cells.

Minoxidil solution can cause skin irritation and allergies in some users.

Methyl vanillate spray increases hair count and hair mass in women with hair loss.

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Rice bran extract caused moderate skin irritation but no eye irritation, while a diluted essence was not irritating to skin and only slightly to guinea pigs.

Rats had lasting erectile problems after stopping a certain medication.

Hair analysis showed very high metformin levels in two fatal overdose cases, suggesting it's useful in forensics but sweat may affect results.

The research shows that hydrogen bonds greatly affect the crystal structure of a Finasteride derivative.

Analog 23 is a promising compound for prostate cancer treatment.

A topical treatment safely and effectively reduced acne by causing targeted cell death in sebaceous glands without side effects.

Dutasteride may protect the brain in early Parkinson's disease.

5α-Reductase inhibitors may increase depression risk but not dementia or suicide.

Adding yeast extract and methyl jasmonate to Eclipta alba cell cultures increased the production of the compound wedelolactone.

Eriocitrin and silymarin might be effective for hair loss treatment and need more research.

The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.

Eclipta alba extract may work as an anticancer agent and help reverse drug resistance.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Radiotherapy was effective for treating a large scalp plaque of Bowen's disease when other treatments failed.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

SCD-153 shows promise as an effective topical treatment for alopecia areata.

Some cancer and immune system drugs can cause serious side effects, including heart, lung, nerve, and organ damage, which need careful monitoring and management.

Finasteride and minoxidil together promote hair growth better than either alone.

Procyanidin compounds from apples and barley promote hair growth and prevent hair cell death.

Finasteride causes abnormal growth in male mice cells at high doses.

Autophagy is crucial for normal sebaceous gland function and sebum composition.