April 2017 in “Journal of Investigative Dermatology” This research explores the potential role of the Stx17 protein in hair pigmentation processes and Alopecia Areata, suggesting possible links to the disease's progression.
2 citations
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May 2022 in “International journal of molecular sciences” This study found that the methylation level at CpG III site 4 of the KRT17 gene promoter significantly influences wool production in Angora rabbits, suggesting its potential as an epigenetic marker for breeding high wool yield.
15 citations
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January 1991 in “Mammalian Genome” October 2025 in “Environment International” This study reports that prenatal and prepubertal exposure to organochlorine compounds and perfluoroalkyl substances may affect pubertal development at age 12, with observed changes in development patterns in both girls and boys, highlighting the need for further research.
January 2022 in “Asian Pacific Journal of Health Sciences” This study assessed the nutritional status of emerging adult women with PCOS and found that while their body measurements were higher than standard, their mean biochemical parameters were within the normal range.
3 citations
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August 2019 in “Journal of The American Academy of Dermatology” Clascoterone safely promotes hair growth similar to minoxidil.
21 citations
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January 2008 in “Journal of Pediatric Endocrinology and Metabolism” This study found that combined treatment with anastrozole and cyproterone acetate improved the adult height prognosis in testotoxicosis, as observed in two brothers, with good tolerance reported.
26 citations
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February 2009 in “Drug Development Research” This article reviews the potential neuroprotective effects of 17α‐estradiol in neurodegenerative diseases and highlights its possibly lower toxicity compared to more feminizing hormones, but it reports no new clinical findings.
271 citations
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December 2005 in “New England journal of medicine/The New England journal of medicine” This article discusses evaluation and treatment options for a 19-year-old woman with slowly progressive hair growth and reports no new clinical findings.
March 2012 in “Journal of Pediatric and Adolescent Gynecology” This study found that BMI was the only significant predictor of elevated androgen levels in adolescents with PCOS, and hyperandrogenemia was not linked to a specific PCOS phenotype.
April 2024 in “The Journal of urology/The journal of urology” In this study, researchers found that methylation of the SRD5A2 gene in blood and tissue samples can serve as a biomarker to predict men's clinical response to finasteride treatment for benign prostatic hyperplasia, offering a non-invasive method for assessing potential treatment success.
212 citations
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May 2010 in “American Journal of Obstetrics and Gynecology” This article suggests using only firm criteria to diagnose polycystic ovary syndrome in adolescents, due to the evolving nature of its features during this period.
October 2023 in “Journal of the Endocrine Society” In this study, distinct androgen excess subtypes were identified in women with PCOS, with the adrenal androgen excess cluster showing significantly higher rates of insulin resistance and type 2 diabetes, suggesting 11-oxygenated androgens as potential drivers of metabolic risk.
September 2021 in “European Neuropsychopharmacology” This study found that higher dihydrotestosterone (DHT) levels in the parietal region of the scalp may be linked to androgenetic alopecia's clinical presentation.
35 citations
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October 2006 in “Journal of Dermatology” This study outlines the clinical features of androgenetic alopecia in Korean adolescents, finding milder symptoms compared to adults and a high occurrence of family history, with normal hormone levels.
7 citations
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January 2015 in “Case reports in genetics” This case report illustrates how SNP array testing helped identify a DCAF17 mutation linked to Woodhouse-Sakati syndrome in consanguineous Qatari siblings with shared features including alopecia and hypogonadotropic hypogonadism.
56 citations
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January 1999 in “The Analyst” This study used gas chromatography-mass spectrometry to simultaneously quantify androstenedione, dihydrotestosterone, dehydroepiandrosterone, testosterone, androsterone, etiocholanolone, progesterone, and pregnenolone in human hair, detecting differences in steroid concentrations between male and female samples.
16 citations
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January 1998 in “Dermatology” This study found that 17β-oestradiol reduces lipogenesis but not cell division in human sebaceous glands over 7 days, while testosterone and dihydrotestosterone showed no effect on these processes.
11 citations
,
June 2016 in “European Journal of Medicinal Chemistry” This study found that two synthesized androst-4-ene-3-one derivatives, 6f and 6g, exhibited stronger anti-proliferative effects than common drugs on prostate cancer cell lines, with low toxicity to rat cells.
July 2024 in “Reproductive health of woman” This study found that teenage girls born via assisted reproductive technologies displayed premature development of secondary sexual characteristics and elevated hormone levels, indicating late precocious puberty and androgen excess.
April 2020 in “Estudo & Debate” This study concluded that the pharmacy in Venâncio Aires complies with Good Manufacturing Practices, as significant microbial growth was only found in Paracetamol samples, while other materials showed no or insignificant growth.
January 2023 in “Austin Journal of Obstetrics and Gynecology” This study found that in a sample of girls and adolescents aged 15–24 years, the prevalence of PCOS was 22.5% according to the Rotterdam criteria.
October 2022 in “Amplla Editora eBooks” Pre-natal, internal, and external factors may contribute to the development of Autism Spectrum Disorder (ASD).
June 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” In male mice and rats, this study found that 17α-estradiol improves metabolic health by acting through estrogen receptor α, suggesting a potential target for treating chronic diseases in male mammals.
November 2022 in “Journal of the Endocrine Society” This case report highlights a novel NR5A1 gene variant associated with a severe 46,XY disorder of sex development, stressing the importance of genetic screening in similar cases.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This case report identified a 6-month-old girl with congenital generalized hypertrichosis and gingival hyperplasia, where a de novo CNV on chromosome 17q24.2-24.3 was associated with reduced expression of ABCA5 and SOX9.
3 citations
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September 2020 in “Journal of developmental and behavioral pediatrics/Journal of developmental & behavioral pediatrics” This case report describes a 4-year-old boy with autism and a rare condition causing precocious puberty, where treatment for hyperandrogenism unexpectedly intensified his aggressive behavior.
10 citations
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September 2021 in “American Journal of Medical Genetics Part A” This study on Qatari patients with Woodhouse-Sakati syndrome highlights the high incidence and diverse clinical presentation due to a specific genetic variant, emphasizing early diagnosis for effective management.
1 citations
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December 2011 in “Arzneimittelforschung” This study found that the compound 9,11-dehydrocortexolone 17alpha-butyrate (CB-03-04) showed strong local antiandrogenic activity in animal models, suggesting potential for treating prostate conditions.
August 2026 in “European Journal of Endocrinology” This case report highlights the growing trend of adolescents using Finasteride off-label for early hair loss, driven by online misinformation and psychological distress, despite potential side effects and hormonal concerns.