Exploring the Genomic Relationship Between Two Major Determinant Phenotypes of Psychiatric Disorders: Human Gut Microbiome and Sleep Traits

A medical student experienced hair loss slowing with Finasteride but developed severe, treatment-resistant insomnia. They tried various medications with little effect, suspecting Post-Finasteride Syndrome, and others suggested the insomnia might be linked to Finasteride's impact on neurosteroids.

The conversation discusses whether lifestyle factors like diet and sleep affect hair growth in people with reversible hair loss. Some believe these factors, along with treatments like minoxidil, finasteride, and RU58841, can improve hair health, while others argue hair loss is mostly determined by genetics and DHT sensitivity.

A user experienced sleep paralysis after starting finasteride and is seeking others' experiences. Another user suggests finasteride might affect neurosteroids, potentially altering sleep patterns.

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

The conversation discusses a personal theory on the role of DHT in stress and reproduction, suggesting it converts testosterone for reproductive traits. The discussion includes skepticism and mentions individual differences in physiology and neurochemistry.

PTD-DBM is being explored for hair regrowth by targeting CXXC5, with clinical trials expected after pre-clinical studies. Users express anticipation and skepticism about its effectiveness.