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Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Testosterone's muscle-building effects do not require its conversion to DHT.

Finasteride may lower cholesterol and slow heart disease progression.

Melasma is a skin condition linked to female hormones, genetics, UV exposure, and certain medications, but not to pituitary, adrenal, or thyroid diseases.

Hyperpigmentation is common in pregnancy and may not fully fade after birth; melasma, also frequent, can persist but has limited treatment options during pregnancy.

The guidelines help doctors diagnose and treat hormone-related disorders in women.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Consider benefits and risks of new alopecia treatments for safety.

Hair growth is influenced by interactions between skin layers, growth factors, and hormones, but the exact mechanisms are not fully understood.

Hair loss, known as Androgenetic Alopecia, is often caused by hormones and can be diagnosed using noninvasive techniques. Treatments include topical minoxidil and oral finasteride, with new treatments being explored. There may also be a link between this type of hair loss and heart disease risk.

Female pattern hair loss is common, linked to polycystic ovarian syndrome, and treated with topical Minoxidil.

Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.

Neuroactive steroids and the enzyme 5α-reductase might be involved in the development of Tourette's syndrome.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Men are more likely to get infectious skin diseases, while women are more prone to autoimmune and pigment-related skin conditions, influenced by biological and environmental factors.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

Menstrual disorders are common in adolescents and can be influenced by weight, activity, and health issues, requiring careful evaluation and more research for effective treatment.

Hirsutism is mainly caused by high androgen levels or sensitivity, with PCOS being the most common cause.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Testosterone and its metabolites have varied effects on different body systems, especially during puberty.

The conclusion is that there is a high demand for new contraceptives that provide both pregnancy prevention and protection against STIs, along with additional health benefits.

Prolactin slows down hair growth in mice.

Hormone therapy increases the risk of heart-related issues in transgender women and may affect heart health in transgender men.

Both mouse and rat models are effective for testing alopecia areata treatments.

Female rats showed more panic-related behavior than males, influenced by hormonal cycles and certain drugs.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Dihydrotestosterone causes p27 protein breakdown in ovarian and breast cancer cells by binding with SKP2.

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.