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Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins.

356 citations , December 1986 in “The journal of cell biology/The Journal of cell biology”

This study found that specific human hair keratins are differentially expressed in the hair follicle, suggesting a shared pathway of epithelial differentiation between hair cortex and nail plate cells.

research Induction of Hard Keratin Expression in Non-Nail-Matrical Keratinocytes by Nail-Matrical Fibroblasts through Epithelial-Mesenchymal Interactions

25 citations , January 2003 in “Plastic & Reconstructive Surgery”

This study indicates that nail-matrical fibroblasts can induce hard keratin expression in non-nail-matrical keratinocytes, suggesting potential for using non-nail-matrical epidermal grafts to treat nail injuries.

research Keratin expression in the normal nail unit: markers of regional differentiation

119 citations , January 2000 in “British Journal of Dermatology”

This study found that keratin expression patterns vary within nail unit structures, with the nail matrix uniquely expressing the acidic hair-type keratin Ha1.

research Keratin film made of human hair as a nail plate model for studying drug permeation

68 citations , February 2011 in “European Journal of Pharmaceutics and Biopharmaceutics”

This study found that keratin films made from human hair can potentially substitute for human nail plates in drug permeability studies, but they show higher sensitivity to penetration enhancers compared to bovine hooves.

research Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b

101 citations , August 2001 in “The Journal of Cell Biology”

This study found that while most mice lacking MK6a and MK6b genes died from tongue epithelium disintegration, about 25% survived and showed no hair or nail defects due to a newly discovered MK6hf gene.

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learn Keratin

What role does keratin play in strengthening weak or thinning hair? Keratin strengthens hair by forming protective structures that prevent breakage and thinning.

learn Alpha Keratin

learn Hydrolyzed Keratin

learn Biotin

supplement to help with hair texture and quality

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Community Join

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community Novel Idea for hair loss treatment using ‘fertiliser’. Almost guaranteed to work.

2 upvotes 8 months ago

A user suggests using a poop-based solution for hair growth, comparing it to fertilizing nails. Others humorously respond, with one mentioning microneedling as a similar concept.

community Reminder: Biotin supplementation is a scam.

114 upvotes 3 years ago

Biotin supplements are considered ineffective for hair loss and are not supported by evidence. People in the conversation have mixed experiences, with some noting benefits for nails and skin but not hair, while others continue to use biotin as part of their vitamin regimen.

community The final nail in the coffin. PP405 is confirmed JXL069.

440 upvotes 1 month ago

PP405 and JXL069 are confirmed to be the same molecule, leading to disappointment due to poor hair regrowth results. Users express skepticism about the credibility of Pelage and the effectiveness of JXL069.

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