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GlossaryChIP-seq (Chromatin Immunoprecipitation Sequencing)

analyzes protein-DNA interactions using chromatin immunoprecipitation and sequencing

ChIP-seq, short for Chromatin Immunoprecipitation Sequencing, is a powerful technique used to analyze protein interactions with DNA. By combining chromatin immunoprecipitation with next-generation sequencing, researchers can identify the binding sites of DNA-associated proteins, such as transcription factors, across the entire genome. This method is crucial for understanding gene regulation and epigenetic mechanisms.

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research In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators

173 citations, January 2014 in “Nature Cell Biology”

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

research Lineage Commitment of Dermal Fibroblast Progenitors Is Mediated by Chromatin De-repression

1 citations, March 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Skin cell types develop when specific genes are turned on by removing certain chemical tags from DNA.

research Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease

January 2018 in “Stem cell biology and regenerative medicine”

The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.

research Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells

77 citations, July 2020 in “Cell”

Muscles and nerves that cause goosebumps also help control hair growth.

research Timing of Expression of the Core Clock Gene Bmal1 Influences Its Effects on Aging and Survival

237 citations, February 2016 in “Science Translational Medicine”

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

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community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.