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Did you mean Chromatin Immunoprecipitation?

Glossary Chromatin Immunoprecipitation

method to study protein-DNA interactions using specific antibodies

Chromatin Immunoprecipitation (ChIP) is a laboratory technique used to investigate the interaction between proteins and DNA within the cell. By using specific antibodies to target and isolate a protein of interest, researchers can identify the DNA sequences that are bound by this protein, providing insights into gene regulation and epigenetic mechanisms.

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research In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators

173 citations , January 2014 in “Nature Cell Biology”

This study found that Wnt signalling activates hair follicle fate in hair follicle stem cells by relieving TCF3/4–TLE-mediated repression, with β-catenin being crucial for this process.

research Lineage Commitment of Dermal Fibroblast Progenitors is Mediated by Chromatin De-repression

1 citations , March 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that Dermal Fibroblast Progenitors have repressed chromatin profiles which hinder their ability to reform skin in allograft assays despite their differentiation potential.

research Transcription factor FOXC1 positively regulates SFRP1 expression in androgenetic alopecia

May 2021 in “Experimental Cell Research”

In this study, SFRP1 expression was found to be upregulated in hair follicles from men with androgenetic alopecia, with the transcription factor FOXC1 playing a significant role in its regulation.

research Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells

8 citations , July 2022 in “International Journal of Molecular Sciences”

This study found that in estrogen receptor-positive breast cancer cells, 17β-estradiol repressed polyamine oxidase transcription by interacting with AP-1 sites on its promoter.

research STAT3 Partly Inhibits Cell Proliferation via Direct Negative Regulation of FST Gene Expression

3 citations , June 2021 in “Frontiers in genetics”

This study found that STAT3 directly inhibited the activity of the sheep FST gene promoter, consequently reducing cell proliferation and promoting a better understanding of hair follicle development mechanisms.

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