21 citations
,
June 2005 in “Alcoholism: Clinical and Experimental Research” This study found that finasteride affected ethanol withdrawal severity differently in WSP and WSR lines, with more modulation seen in the WSP line.
134 citations
,
February 2005 in “Neuropsychopharmacology” GABRA2 gene variations impact alcohol response, and hair loss medication finasteride reduces some effects.
26 citations
,
August 2004 in “Alcoholism Clinical and Experimental Research” This study found that ethanol-induced deficits in motor coordination in rats are not mediated by elevated neuroactive steroid biosynthesis.
29 citations
,
June 2004 in “Pharmacology, Biochemistry and Behavior” Finasteride reduces alcohol withdrawal effects, especially in female mice.
83 citations
,
January 2004 in “Pharmacology & Therapeutics” This review explores the potential role of pregnane neurosteroids in modulating alcohol withdrawal symptoms, suggesting a therapeutic target for treating alcohol dependence, but reports no new clinical results.
136 citations
,
January 2004 in “Neuroscience” This study found that testosterone increased seizure severity in mice and rats, with its neurosteroid metabolites playing a role in modulating seizure susceptibility.
47 citations
,
November 2002 in “Journal of Neurochemistry” This study found that progesterone pretreatment in rats potentiated the effect of ethanol on mesocortical dopamine levels, suggesting an influence of neuroactive steroids on ethanol's action.
269 citations
,
May 2002 in “Journal of Neuroscience” This study observed that acute stress in rats increased neurosteroid levels linked to enhanced GABA(A) receptor function, raising seizure thresholds, while similar effects were seen in mice with deoxycorticosterone administration.
60 citations
,
December 1998 in “Clinical Pharmacology & Therapeutics” Both drugs lower DHT levels, with GI198745 being more effective.
98 citations
,
April 1997 in “The Journal of Steroid Biochemistry and Molecular Biology” Finasteride effectively blocks rat enzymes, but with varying methods and strength.