Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis

    Christian F. Guerrero-Juarez, A. A. Astrowski, Rabi Murad, Christina T. Dang, V. O. Shatrova, A. B. Astrowskaja, Churlzu Lim, Raul Ramos, Xiaojie Wang, Yuchen Liu, Hye-Lim Lee, Kim Pham, Tsai-Ching Hsi, Ji Won Oh, Daniel E. Crocker, A Mortazavi, Mayumi Ito, Maksim V. Plikus
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    TLDR Rats can't grow new hair follicles after skin wounds, unlike mice, due to differences in gene expression and response to WNT signaling.
    The study conducted on May 31, 2018, investigated the wound healing process in rats and mice, specifically focusing on hair follicle regeneration. The researchers found that rats, unlike mice, failed to regenerate new hair follicles after excisional wounding, despite complete re-epithelialization occurring within 25-33 days. This was observed across seven strains of rats. Transcriptome profiling revealed distinct gene expression patterns between rats and mice, suggesting that the wound epidermis in rats was less mature and less responsive to WNT signaling compared to mice. The study concluded that rats could serve as a suitable model for studying non-regenerative healing of large excisional skin wounds.
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