Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis

June 2018 in “ Journal of Investigative Dermatology ”

Christian F. Guerrero-Juarez, A. A. Astrowski, Rabi Murad, Christina T. Dang, V. O. Shatrova, A. B. Astrowskaja, Churlzu Lim, Raul Ramos, Xiaojie Wang, Yuchen Liu, Hye-Lim Lee, Kim Pham, Tsai-Ching Hsi, Ji Won Oh, Daniel E. Crocker, A Mortazavi, Mayumi Ito, Maksim V. Plikus

hair follicle regeneration excisional wounding re-epithelialization transcriptome profiling gene expression WNT signaling wound epidermis non-regenerative healing skin wounds hair growth skin healing gene activity WNT pathway skin layer wound healing

TLDR Rats can't grow new hair follicles after skin wounds, unlike mice, due to differences in gene expression and response to WNT signaling.

The study conducted on May 31, 2018, investigated the wound healing process in rats and mice, specifically focusing on hair follicle regeneration. The researchers found that rats, unlike mice, failed to regenerate new hair follicles after excisional wounding, despite complete re-epithelialization occurring within 25-33 days. This was observed across seven strains of rats. Transcriptome profiling revealed distinct gene expression patterns between rats and mice, suggesting that the wound epidermis in rats was less mature and less responsive to WNT signaling compared to mice. The study concluded that rats could serve as a suitable model for studying non-regenerative healing of large excisional skin wounds.

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research Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis

37 citations , November 2017 in “Journal of Investigative Dermatology”

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29 citations , May 2017 in “Journal of Investigative Dermatology”

The Msi2 protein helps keep hair follicle stem cells inactive, controlling hair growth and regeneration.

research Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF

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Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

research Regeneration of Fat Cells from Myofibroblasts During Wound Healing

408 citations , February 2017 in “Science”

Some wound-healing cells can turn into fat cells around new hair growth in mice.

research Interleukin 6 and STAT3 Regulate p63 Isoform Expression in Keratinocytes During Regeneration

11 citations , January 2016 in “Experimental Dermatology”

The conclusion is that the IL-6/STAT3 activation affects p63 expression in healing wounds, which may help in hair follicle regeneration.

research dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration

128 citations , August 2015 in “Cell Stem Cell”

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

research Principles and Mechanisms of Regeneration in the Mouse Model for Wound-Induced Hair Follicle Neogenesis

46 citations , June 2015 in “Regeneration”

Mice can grow new hair follicles after skin wounds through a process not involving existing hair stem cells, but requiring more research to understand fully.

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237 citations , June 2013 in “Nature Medicine”

A protein from certain immune cells is key for new hair growth after skin injury in mice.

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68 citations , April 2013 in “Journal of Investigative Dermatology”

Prostaglandin D2 blocks new hair growth after skin injury through the Gpr44 receptor.

research Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration

170 citations , January 2013 in “Journal of Investigative Dermatology”

Wnt ligands are crucial for hair growth and repair.

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418 citations , September 2012 in “Nature”

African spiny mice can regenerate skin, hair, and cartilage, but not muscle, and their unique abilities could be useful for regenerative medicine.

research Review of Hair Follicle Dermal Cells

321 citations , January 2010 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.

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96 citations , September 2007 in “Journal of Investigative Dermatology”

Grafted rodent and human cells can regenerate hair follicles, but efficiency decreases with age.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

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research The Formation of Vellus Hair Follicles from Human Adult Epidermis

73 citations , July 1956 in “Journal of Investigative Dermatology”

Adult human skin can grow new fine hair follicles after a deep exfoliation treatment.